locus-tag class description Aa23R_1001 ENOG4107BJW polysaccharide deacetylase Aa23R_1011 ENOG4107S47 Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC) (By similarity) Aa23R_1022 ENOG4105C2M dna polymerase I Aa23R_1040 ENOG4105BZU Histidine kinase Aa23R_1043 ENOG4105DEK Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) Aa23R_1048 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) Aa23R_1049 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) Aa23R_1051 ENOG4105EMY transcriptional regulator Aa23R_1055 ENOG4108WI1 Dna topoisomerase Aa23R_1062 ENOG41063SR receptor Aa23R_1070 ENOG4105KNE Phosphatidate cytidylyltransferase Aa23R_1080 ENOG4107QWE )-transporter Aa23R_1082 ENOG4108HPI phosphatidate Cytidylyltransferase Aa23R_1087 ENOG4105KME endoribonuclease L-psp Aa23R_1112 ENOG4108V1T peptidylprolyl cis-trans isomerase Aa23R_1124 ENOG4105CBT Fructose-1,6-bisphosphatase Aa23R_1146 ENOG4105EKX Restriction modification system DNA (Specificity Aa23R_116 ENOG4105X5C UPF0181 protein Aa23R_1179 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) Aa23R_118 ENOG4105WP7 tRNA pseudouridine synthase C Aa23R_1184 ENOG4106NZV Responsible for synthesis of pseudouridine from uracil- 13 in transfer RNAs (By similarity) Aa23R_1185 ENOG4105CV2 Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates (By similarity) Aa23R_1188 ENOG4108K5P (LipO)protein Aa23R_120 ENOG4107R1K Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity) Aa23R_121 ENOG4107TXD phosphoglycerate transport system transcriptional regulatory protein pgta Aa23R_1221 ENOG4107YUN Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division (By similarity) Aa23R_1224 ENOG4105C34 Pseudouridine synthase Aa23R_1233 ENOG410624X efflux transporter, rnd family, mfp subunit Aa23R_1294 ENOG4105CB9 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY Aa23R_13 ENOG4105D0S secretion protein (HlyD Aa23R_131 ENOG4107S6Z Na H antiporter Aa23R_1321 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) Aa23R_1327 ENOG4107RK2 ADP-ribose diphosphatase NudE Aa23R_1333 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase Aa23R_1334 ENOG4108Q79 6-phosphogluconolactonase (EC 3.1.1.31) Aa23R_1342 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) Aa23R_1366 ENOG4105CXB phosphoribosylaminoimidazole synthetase Aa23R_1377 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) Aa23R_1396 ENOG4108RS6 transposase Aa23R_1407 ENOG4108UUE Transcriptional regulator Aa23R_1410 ENOG4105DQ6 Transposase Aa23R_1435 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) Aa23R_1437 ENOG4107QKW extracellular solute-binding protein family 1 Aa23R_1439 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) Aa23R_144 ENOG4105EZE Cupin 4 family protein Aa23R_1449 ENOG4106I92 NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) Aa23R_146 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) Aa23R_1461 ENOG4105QF0 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) Aa23R_147 ENOG4107RM2 PTS IIA-like nitrogen-regulatory protein PtsN Aa23R_1512 ENOG4105MA0 exported protein Aa23R_1539 ENOG4105XQ6 frataxin-like protein Aa23R_154 ENOG4105E3I toluene tolerance Aa23R_1541 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) Aa23R_1544 ENOG4105E7H involved in the assembly of LPS in the outer leaflet of the outer membrane. Determines N-hexane tolerance and is involved in outer membrane permeability. Essential for envelope biogenesis (By similarity) Aa23R_1588 ENOG4105GBT ABC transporter Aa23R_1604 ENOG4105K7E Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly (By similarity) Aa23R_1628 ENOG4105CAP With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P (By similarity) Aa23R_1641 ENOG4105R9M This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region (By similarity) Aa23R_1642 ENOG4107SC1 transglycosylase Aa23R_1649 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) Aa23R_1659 ENOG4105EMA Periplasmic binding protein LacI transcriptional regulator Aa23R_1660 ENOG41060NJ transcriptional regulator Aa23R_1666 ENOG4107QPK )-transporter Aa23R_1696 ENOG4105C4Y ABC transporter Aa23R_171 ENOG4105C5F glutamine synthetase Aa23R_1712 ENOG4106BMH cytolethal distending toxin Aa23R_1713 ENOG4108TMH cytolethal distending toxin Aa23R_1782 ENOG4105CDU Replicative dna helicase Aa23R_1790 ENOG4105CFG Acts as a chaperone (By similarity) Aa23R_18 ENOG4105E0A ABC, transporter Aa23R_1804 ENOG4105EEI dihydropteroate synthase Aa23R_1811 ENOG4105IYK transposase Aa23R_1817 ENOG4108JQ3 Peptide ABC transporter ATP-binding protein Aa23R_1842 ENOG4105WD1 Membrane Aa23R_1856 ENOG4107QP8 phosphohexose isomerase Aa23R_1860 ENOG4108ZAI phosphatidylglycerophosphatase a Aa23R_1870 ENOG4105C4Y ABC transporter Aa23R_1885 ENOG4105HBR Rna-binding protein Aa23R_1896 ENOG4105D1U peptidase U62 modulator of DNA gyrase Aa23R_1897 ENOG4105DN3 alpha-2-macroglobulin domain protein Aa23R_19 ENOG4105S10 periplasmic binding protein Aa23R_1906 ENOG4107R0P L-ribulose-5-phosphate 4-epimerase Aa23R_1907 ENOG4105E0U tyrosine-specific transport protein Aa23R_1909 ENOG4105CNT hydrolase family 2 Aa23R_1954 ENOG4105F9E Shikimate 5-dehydrogenase Aa23R_1961 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein Aa23R_1965 ENOG4105C0H protease Aa23R_1967 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) Aa23R_199 ENOG4108UHU Aldolase Aa23R_2006 ENOG4105CE6 Adenylation and deadenylation of glutamate--ammonia ligase (By similarity) Aa23R_2009 ENOG4105FB9 CRISPR-associated protein Aa23R_201 ENOG4105DMW Dehydrogenase reductase Aa23R_2024 ENOG4105EIP mannose-6-phosphate isomerase Aa23R_203 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit Aa23R_2031 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) Aa23R_2067 ENOG4107QMH DNA methylase Aa23R_2073 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) Aa23R_2103 ENOG41061ZR Transcriptional regulator Aa23R_211 ENOG4105CHH sulfate transporter Aa23R_2115 ENOG4107R11 Transcriptional regulator Aa23R_212 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) Aa23R_2151 ENOG4105D2M Aldolase Aa23R_2153 ENOG41082GB PTS system galactitol-specific transporter subunit IIA Aa23R_2154 ENOG41090UW PTS System Aa23R_2195 ENOG4105DUC Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division (By similarity) Aa23R_22 ENOG4107RNH Outer membrane receptor FepA Aa23R_231 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase Aa23R_265 ENOG4105C9S Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P) (By similarity) Aa23R_269 ENOG4105CI1 PTS System Aa23R_273 ENOG41065CD Exported protein Aa23R_282 ENOG4108VTV Inherit from NOG: Membrane Aa23R_307 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) Aa23R_311 ENOG4107RAN Peptidase, M16 Aa23R_339 ENOG4105C5H ABC transporter Aa23R_34 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) Aa23R_371 ENOG4105F3T (LipO)protein Aa23R_376 ENOG4105C1B dTDP-glucose 4-6-dehydratase Aa23R_378 ENOG4105GXY Family of unknown function (DUF695) Aa23R_40 ENOG4105CRQ synthase (Component I) Aa23R_422 ENOG4108WTW DNA transposition protein Aa23R_424 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein Aa23R_430 ENOG4107TDF Formate hydrogenlyase subunit 4 Aa23R_440 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) Aa23R_449 ENOG4105DIT ErfK YbiS YcfS YnhG family protein Aa23R_450 ENOG4105CN1 protease Aa23R_454 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) Aa23R_457 ENOG4105D38 putrescine abc transporter Aa23R_464 ENOG4105CNU cell division protein FtsK Aa23R_467 ENOG4105I7R Adenylate cyclase Aa23R_480 ENOG4107QM1 Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) Aa23R_485 ENOG4105CIH Imidazole acetol-phosphate transaminase Aa23R_486 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase Aa23R_506 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator Aa23R_511 ENOG4105ECY inositol monophosphatase Aa23R_514 ENOG4105D7K pfkb domain protein Aa23R_52 ENOG4105D9Q decarboxylase (Beta subunit) Aa23R_520 ENOG4107SQ3 mannitol-1-phosphate 5-dehydrogenase Aa23R_543 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii Aa23R_552 ENOG4105K3M )-transporter Aa23R_568 ENOG4105WPN DNA integration recombination invertion protein Aa23R_581 ENOG4105C3U ABC transporter Aa23R_582 ENOG4108JQ7 (ABC) transporter Aa23R_585 ENOG4105NRA 50s ribosomal protein l31 type b Aa23R_589 ENOG4105C03 ribonuclease Aa23R_609 ENOG4108VPT UPF0234 protein Aa23R_610 ENOG4105EAC phosphoserine phosphatase Aa23R_630 ENOG4105C0F tryptophanase EC 4.1.99.1 Aa23R_640 ENOG4105TMB Formate nitrite transporter Aa23R_668 ENOG4105DQ6 Transposase Aa23R_67 ENOG4105EMU Dehydrogenase Aa23R_68 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) Aa23R_689 ENOG4105CA5 Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes (By similarity) Aa23R_708 ENOG4107ZVW dihydroneopterin aldolase Aa23R_715 ENOG4105E4F Isochorismate synthase Aa23R_716 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) Aa23R_724 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs Aa23R_749 ENOG4108R96 Methyltransferase, YaeB family Aa23R_752 ENOG4105C8P )-transporter Aa23R_768 ENOG4105D7Q type ii secretion system Aa23R_798 ENOG4108Z6B deaminase Aa23R_816 ENOG4108IQE Amp-dependent synthetase and ligase Aa23R_82 ENOG4105DKT Transcriptional regulator Aa23R_839 ENOG4107RGD Major Facilitator superfamily Aa23R_852 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) Aa23R_898 ENOG4108VZM 50s ribosomal protein L10 Aa23R_922 ENOG4105C5B carbamate kinase Aa23R_97 ENOG4105D8I Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity) Aa23R_986 ENOG4105CIC tryptophan-specific transport protein Aa23R_987 ENOG4105F0N pyrophosphate phospho-hydrolase Aa23R_988 ENOG4105ERG peptidase m48, ste24p Aa23R_989 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) Aa23R_992 ENOG4106H78 methyltransferase Aa23R_994 ENOG4105ETZ PTS System Aa23S_10 ENOG4105C6K Malic enzyme Aa23S_100 ENOG4105C6Y Udp-glucose 6-dehydrogenase Aa23S_1005 ENOG4105CHY citrate lyase, alpha Aa23S_1006 ENOG4105CI0 Citrate lyase Aa23S_1008 ENOG4105DUA (citrate (pro-3S)-lyase ligase Aa23S_1019 ENOG4105WVQ Fe-S assembly protein IscX Aa23S_1041 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis Aa23S_1044 ENOG4105C03 ribonuclease Aa23S_1071 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj Aa23S_1101 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) Aa23S_1109 ENOG4108UUM single-stranded DNA-binding protein Aa23S_1120 ENOG4105CDU Replicative dna helicase Aa23S_1135 ENOG4107TT5 NLP P60 protein Aa23S_1137 ENOG4105K7U Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity) Aa23S_1142 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) Aa23S_1149 ENOG4105DQ6 Transposase Aa23S_1151 ENOG4105HJX Biotin- acetyl-CoA-carboxylase ligase Aa23S_1169 ENOG410838F Glycosyl transferase family 2 Aa23S_1183 ENOG4105DDQ anthranilate synthase Aa23S_1188 ENOG4105D60 lipoprotein releasing system transmembrane protein Aa23S_1204 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) Aa23S_1208 ENOG4107RCV ABC transporter, permease Aa23S_1210 ENOG4107T9C Alpha amylase catalytic region Aa23S_1211 ENOG4105EG2 ABC transporter, permease Aa23S_1219 ENOG4105EUJ GTP cyclohydrolase i Aa23S_1220 ENOG4106HRJ d-alanyl-d-alanine carboxypeptidase Aa23S_1223 ENOG4105VUH addiction module killer protein Aa23S_1229 ENOG4107XNE ABC transporter, periplasmic molybdate-binding protein Aa23S_1248 ENOG4108DBC nitroreductase Aa23S_1251 ENOG4105RHG Aa23S_1252 ENOG4105C9Q fumarate hydratase class II Aa23S_1262 ENOG4105CAF HipA N-terminal domain protein Aa23S_1264 ENOG4105C0R drug resistance transporter emrb qaca subfamily Aa23S_1272 ENOG4105CRK lysyL-tRNA synthetase Aa23S_1284 ENOG4107RSS Hydrogenase accessory protein HypB Aa23S_1295 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) Aa23S_13 ENOG4107QX9 Thiol disulfide interChange protein Aa23S_1301 ENOG4105DK2 UPF0207 protein Aa23S_1305 ENOG4105EZ6 Catalyzes the 2'-O-methylation at nucleotide C2498 in 23S rRNA (By similarity) Aa23S_1306 ENOG4105ETT transcriptional Regulator, LysR family Aa23S_1309 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) Aa23S_1317 ENOG4105DZB Electron transport complex Aa23S_1323 ENOG4108IPW abc transporter atp-binding protein Aa23S_1332 ENOG4107H6E Aa23S_1336 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) Aa23S_1352 ENOG4105DYN CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. May be involved in the integration of spacer DNA into the CRISPR cassette (By similarity) Aa23S_1363 ENOG4105KWI UPF0339 protein Aa23S_14 ENOG4105DA4 cytochrome c-type biogenesis protein Aa23S_1407 ENOG4105KG7 Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) Aa23S_1414 ENOG4105C15 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) Aa23S_1438 ENOG4105E96 Colicin v production protein Aa23S_1440 ENOG4107QQN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) Aa23S_1443 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) Aa23S_1444 ENOG4107QSN dihydrolipoamide acetyltransferase Aa23S_1448 ENOG4105D07 Signal peptide peptidase, SppA Aa23S_146 ENOG4105CNN ABC, transporter Aa23S_1466 ENOG4105E0X reductase Aa23S_1468 ENOG4105W4M Transport-associated protein Aa23S_1477 ENOG4105ERU peptidase Aa23S_148 ENOG4108RVA ribokinase Aa23S_1498 ENOG4105CTB Polyprenyl synthetase Aa23S_1501 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase Aa23S_1515 ENOG4105ENJ RND efflux system, outer membrane lipoprotein Aa23S_1522 ENOG4108ESZ Glycogen debranching enzyme Aa23S_1533 ENOG4105DAH Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF (By similarity) Aa23S_1571 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) Aa23S_1573 ENOG4107QYT Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity) Aa23S_1578 ENOG4105CJ1 ABC, transporter Aa23S_1587 ENOG4107RNH Outer membrane receptor FepA Aa23S_1588 ENOG4105E0A ABC, transporter Aa23S_1589 ENOG4105EHG Permease protein Aa23S_1607 ENOG4107QYG anthranilate phosphoribosyltransferase Aa23S_1628 ENOG4108MVK Receptor Aa23S_1669 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) Aa23S_167 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) Aa23S_1686 ENOG4105CK6 Two component transcriptional regulator (Winged helix family Aa23S_1693 ENOG4105CIY formyltetrahydrofolate deformylase Aa23S_1700 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) Aa23S_1716 ENOG4107PE3 Mammalian cell entry related domain protein Aa23S_1748 ENOG4105D98 threonine synthase Aa23S_175 ENOG4105CJN penicillin-binding protein Aa23S_1750 ENOG4107QJR hflk protein Aa23S_1756 ENOG4105CSA Coproporphyrinogen iii oxidase Aa23S_1757 ENOG4105E66 phosphoriboisomerase A Aa23S_1769 ENOG4107YCY Transcriptional regulator Aa23S_177 ENOG4105KEM Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity) Aa23S_1781 ENOG4107104 thymidine kinase Aa23S_1784 ENOG4105EXN Sulfate transport protein CysZ Aa23S_1785 ENOG4105C6T cysteine synthase Aa23S_1793 ENOG4105E1P Modifies, by uridylylation or deuridylylation the PII (GlnB) regulatory protein (By similarity) Aa23S_1794 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) Aa23S_1801 ENOG4107RBB ABC transporter, permease Aa23S_1803 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) Aa23S_1811 ENOG4105CQ7 ATP-dependent helicase Aa23S_1812 ENOG4105M08 Membrane Aa23S_1818 ENOG4105KA0 thioesterase Superfamily protein Aa23S_1820 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) Aa23S_1824 ENOG4105QEK Transcriptional regulator Aa23S_1828 ENOG4105CG6 trap dicarboxylate transporter dctm subunit Aa23S_1845 ENOG4105M4H endoribonuclease L-psp Aa23S_1849 ENOG4107QMP dna polymerase iii subunits gamma and tau Aa23S_1861 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) Aa23S_1867 ENOG41080YA This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) Aa23S_1878 ENOG4105DFS Conserved Protein Aa23S_188 ENOG4105FCQ metal-binding, possibly nucleic acid-binding protein Aa23S_1885 ENOG4105CC5 ABC transporter Aa23S_1888 ENOG41068P6 UPF0319 protein Aa23S_1890 ENOG410901E Membrane Aa23S_1891 ENOG4105EM2 membrane Aa23S_190 ENOG41090JN Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) Aa23S_1924 ENOG4107QR8 Thioredoxin Aa23S_194 ENOG4105DJ4 phosphatidylserine decarboxylase Aa23S_1942 ENOG4105D3Q Sugar transferase Aa23S_1957 ENOG4105C1B dTDP-glucose 4-6-dehydratase Aa23S_198 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) Aa23S_1984 ENOG4106YXT transposase Aa23S_1986 ENOG4108MG3 formate dehydrogenase Aa23S_1989 ENOG4108MFN small subunit of hydrogenase-3, iron-sulfur protein (part of formate hydrogenlyase (FHL) complex) Aa23S_1990 ENOG4108JPZ Monovalent cation H antiporter subunit D Aa23S_1992 ENOG4105D65 subunit l Aa23S_1995 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) Aa23S_1996 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) Aa23S_2009 ENOG4105EAQ (twin-arginine translocation) pathway signal Aa23S_2019 ENOG4107RUE extracellular solute-binding protein family 1 Aa23S_2023 ENOG4105D1H recombination factor protein RarA Aa23S_2030 ENOG4105CJ3 phosphate transporter Aa23S_2033 ENOG4108AD6 Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein (By similarity) Aa23S_2055 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) Aa23S_2064 ENOG4105C0A alcohol dehydrogenase Aa23S_2083 ENOG4105C42 Type I secretion membrane fusion protein (HlyD Aa23S_2085 ENOG4105DDI hemolysin-type calcium-binding region Aa23S_2097 ENOG4107R6Y Involved in the TonB-independent uptake of proteins (By similarity) Aa23S_2111 ENOG4105CDY transcriptional regulatory protein Aa23S_2115 ENOG4105C9M aspartyl-trna synthetase Aa23S_2135 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control Aa23S_2138 ENOG4108J59 Extracellular solute-binding protein, family 5 Aa23S_214 ENOG4105C6Z Gluconate Aa23S_2141 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component Aa23S_2155 ENOG4105C28 cystathionine Aa23S_2164 ENOG4105CZI D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1 Aa23S_2175 ENOG4105DTN riboflavin biosynthesis protein ribF Aa23S_2181 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) Aa23S_2187 ENOG4108UBT opacity-associated protein Aa23S_2193 ENOG4105WWK YheO domain protein Aa23S_2202 ENOG4105K59 histidine triad (HIT) protein Aa23S_2212 ENOG4108VKA Acts as a radical domain for damaged PFL and possibly other radical proteins (By similarity) Aa23S_2219 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) Aa23S_240 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) Aa23S_248 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) Aa23S_252 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) Aa23S_255 ENOG4105CMU LysR family (Transcriptional regulator Aa23S_257 ENOG4107QP7 CoA-transferase subunit A Aa23S_259 ENOG4105CRW Short chain fatty acid transporter Aa23S_269 ENOG4108I5U Uridine phosphorylase Aa23S_27 ENOG4105X3C heme exporter protein Aa23S_301 ENOG4105CS6 Rhs element vgr protein Aa23S_314 ENOG4105C0P Mg chelatase subunit ChlI Aa23S_322 ENOG4105C4N this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity) Aa23S_343 ENOG4105CND Glycosyl transferase, family 2 Aa23S_345 ENOG4105CXY transporter Aa23S_367 ENOG4105CGH 5'-nucleotidase Aa23S_382 ENOG4105D4A Cell wall formation (By similarity) Aa23S_39 ENOG4105C2C drug resistance transporter, Bcr CflA Aa23S_394 ENOG4105E2X shikimate dehydrogenase Aa23S_398 ENOG4108TEB UPF0114 protein Aa23S_4 ENOG4105DVA methyltransferase Aa23S_40 ENOG4105I08 Pseudouridine synthase Aa23S_401 ENOG4105EBW Rhomboid-type serine protease that catalyzes intramembrane proteolysis (By similarity) Aa23S_418 ENOG4105D0V Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) Aa23S_42 ENOG4105C6K Malic enzyme Aa23S_423 ENOG4108RIR Molybdenum cofactor biosynthesis protein Aa23S_426 ENOG4105CV1 Transketolase (EC 2.2.1.1) Aa23S_458 ENOG4108JJ9 ABC, transporter Aa23S_465 ENOG4105N4M Non-essential, abundant cell division factor that is required for proper Z-ring formation. It is recruited early to the divisome by direct interaction with FtsZ, stimulating Z-ring assembly and thereby promoting cell division earlier in the cell cycle. Its recruitment to the Z-ring requires functional FtsA or ZipA (By similarity) Aa23S_466 ENOG4105QTB Flavodoxin Aa23S_469 ENOG4105KVH Transcriptional regulator Aa23S_479 ENOG4105KNM Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) Aa23S_54 ENOG4105CHM Aminotransferase Aa23S_546 ENOG4105CXY transporter Aa23S_558 ENOG4107RAQ aminopeptidase Aa23S_562 ENOG4106SNF Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane Aa23S_569 ENOG4107QUT magnesium and cobalt transport protein CorA Aa23S_607 ENOG4105DQ6 Transposase Aa23S_61 ENOG4105C44 Serine transporter Aa23S_631 ENOG4105C4W S-formylglutathione hydrolase Aa23S_636 ENOG4105M8K biopolymer transport protein Aa23S_65 ENOG41090FY type IV pilus biogenesis stability protein PilW Aa23S_654 ENOG41063VX Inherit from COG: glutaredoxin-related protein Aa23S_659 ENOG4105D52 delta-aminolevulinic acid dehydratase Aa23S_668 ENOG4108KBJ Inner membrane protein YkgB Aa23S_68 ENOG4105CUT histidyl-tRNA synthetase Aa23S_683 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) Aa23S_69 ENOG4105N21 Membrane Aa23S_711 ENOG4105MJ2 Competence protein Aa23S_716 ENOG4108RS6 transposase Aa23S_735 ENOG4105E0U tyrosine-specific transport protein Aa23S_737 ENOG4107VZS Nicotinamide-nucleotide adenylyltransferase Aa23S_755 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) Aa23S_759 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) Aa23S_761 ENOG41071DT Involved in DNA repair and RecF pathway recombination (By similarity) Aa23S_762 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) Aa23S_765 ENOG4106XY2 Folate-binding protein involved in regulating the level of ATP-DnaA and in the modification of some tRNAs. It is probably a key factor in regulatory networks that act via tRNA modification, such as initiation of chromosomal replication (By similarity) Aa23S_788 ENOG4108IUB NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) Aa23S_797 ENOG4108UJU UPF0301 protein Aa23S_803 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) Aa23S_805 ENOG4105DXN mazG family Aa23S_811 ENOG4105E3W Two component transcriptional regulator (Winged helix family Aa23S_812 ENOG4105E0F Histidine kinase Aa23S_82 ENOG4105NX3 Membrane Aa23S_851 ENOG4105WH1 Two component transcriptional regulator luxr family Aa23S_853 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) Aa23S_863 ENOG4108TGR phosphatase Aa23S_868 ENOG4105CMG Carbohydrate kinase Aa23S_875 ENOG4105C9U ATP-dependent DNA helicase RecQ Aa23S_893 ENOG4105C1Y Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis (By similarity) Aa23S_894 ENOG4105EM7 Selenocysteine-specific translation elongation factor Aa23S_921 ENOG4108JA2 transcriptioN-repair coupling factor Aa23S_937 ENOG4105CNI cell division protein FtsW Aa23S_943 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) Aa23S_963 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) Aa23S_966 ENOG4105E0A ABC, transporter Aa23S_97 ENOG4107QQ0 gntp family Aa23S_973 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) Aa23S_977 ENOG4108VKV Monofunctional biosynthetic peptidoglycan transglycosylase Aa23S_995 ENOG4105C2J ABC transporter Aa30R_1014 ENOG4105CWG Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 (By similarity) Aa30R_1017 ENOG4108HWV )-transporter Aa30R_1018 ENOG4105C2J ABC transporter Aa30R_1019 ENOG4105EMA Periplasmic binding protein LacI transcriptional regulator Aa30R_1021 ENOG4105F0Z galactose-1-phosphate uridylyltransferase Aa30R_103 ENOG4108QUU Morphogenesis Protein Aa30R_1034 ENOG4105CE8 Transfers the fatty acyl group on membrane lipoproteins (By similarity) Aa30R_104 ENOG4105QIB mu-like prophage Flumu protein gp29 Aa30R_1040 ENOG4105D1F ATP-binding protein Aa30R_105 ENOG4105CF2 Mu-like prophage FluMu protein GP28 Aa30R_1060 ENOG4105F27 Major Facilitator Aa30R_1066 ENOG4105CK7 Sodium proline symporter Aa30R_1068 ENOG4105E9S glutaredoxin 2 Aa30R_1069 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) Aa30R_1084 ENOG4105CFG Acts as a chaperone (By similarity) Aa30R_1087 ENOG4105NBI YecM protein Aa30R_109 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) Aa30R_1094 ENOG4105K7U Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity) Aa30R_1096 ENOG4108BY2 phosphohistidine phosphatase Aa30R_1103 ENOG4105HJX Biotin- acetyl-CoA-carboxylase ligase Aa30R_1118 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase Aa30R_1124 ENOG4108I6E Sulfatase Aa30R_1134 ENOG4105CRQ synthase (Component I) Aa30R_1144 ENOG4107QP8 phosphohexose isomerase Aa30R_1149 ENOG4105CCF Lysine exporter protein (Lyse ygga) Aa30R_1160 ENOG4107RCV ABC transporter, permease Aa30R_1162 ENOG4107T9C Alpha amylase catalytic region Aa30R_1167 ENOG4108KDD Involved in the transport of maltose and maltodextrins (By similarity) Aa30R_1168 ENOG4107W52 maltose operon periplasmic protein Aa30R_1177 ENOG4105YES addiction module antidote protein Aa30R_1180 ENOG4108Z66 YbaK ebsC protein Aa30R_1184 ENOG4108VEN abc transporter atp-binding protein Aa30R_119 ENOG4108YYX Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. Modulates RNA-binding and helicase activities of the degradosome (By similarity) Aa30R_1196 ENOG4107R0P L-ribulose-5-phosphate 4-epimerase Aa30R_1220 ENOG4107QNR UPF0135 protein Aa30R_1227 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) Aa30R_1231 ENOG4108A51 Aa30R_1237 ENOG4105C45 hydrogenase expression formation protein (HypE) Aa30R_1240 ENOG4106YXT transposase Aa30R_1252 ENOG4105F4R Transcriptional regulator mode Aa30R_1284 ENOG4105XJC Two component transcriptional regulator (Winged helix family Aa30R_1287 ENOG4107H6E Aa30R_1289 ENOG4105XJC Two component transcriptional regulator (Winged helix family Aa30R_129 ENOG4105C1J atp-dependent rna helicase Aa30R_1290 ENOG4105DHQ Histidine kinase Aa30R_1296 ENOG4105XUP Phage derived protein Gp49-like (DUF891) Aa30R_130 ENOG4105RT1 May be involved in cell division (By similarity) Aa30R_1309 ENOG4105EIP mannose-6-phosphate isomerase Aa30R_1311 ENOG4105CI1 PTS System Aa30R_132 ENOG4108R66 Conserved Protein Aa30R_1320 ENOG4105CMR udp-glucose 4-epimerase Aa30R_1322 ENOG4105C7N Xanthine uracil vitamin C permease Aa30R_1349 ENOG4107QMH DNA methylase Aa30R_1352 ENOG4105C0D helicase Aa30R_1375 ENOG4108EQH DNA internalization-related competence protein ComEC Rec2 Aa30R_1377 ENOG4105DJ0 Poly(A) Polymerase Aa30R_1400 ENOG4107R11 Transcriptional regulator Aa30R_1401 ENOG4105DMJ Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate (By similarity) Aa30R_1430 ENOG41082NX 50s ribosomal protein l35 Aa30R_1447 ENOG4105DWU Membrane Aa30R_145 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) Aa30R_1472 ENOG41061WM D-Alanyl-D-Alanine Aa30R_1473 ENOG41061WM D-Alanyl-D-Alanine Aa30R_1474 ENOG4105GHU Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity (By similarity) Aa30R_1476 ENOG4105CEY Amp-dependent synthetase and ligase Aa30R_1492 ENOG4105Q9Y Universal stress protein Aa30R_1494 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) Aa30R_15 ENOG41088T4 Helicase IV Aa30R_1502 ENOG4105CMI transporter Aa30R_1511 ENOG4105EHG Permease protein Aa30R_1520 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) Aa30R_1521 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) Aa30R_1527 ENOG4105CRQ synthase (Component I) Aa30R_1533 ENOG4105DK0 Indole-3-glycerol phosphate synthase Aa30R_1534 ENOG4105DK0 Indole-3-glycerol phosphate synthase Aa30R_1542 ENOG4108MVK Receptor Aa30R_1543 ENOG4108MVK Receptor Aa30R_1545 ENOG4105EMU Dehydrogenase Aa30R_1561 ENOG4107RYS Autoinducer-2 (AI-2) kinase Aa30R_1563 ENOG4105DAG ROK family Aa30R_1564 ENOG4105C5S asparaginyl-tRNA synthetase Aa30R_1589 ENOG4108RKI Necessary for the introduction of cis unsaturation into fatty acids. Catalyzes the dehydration of (3R)-3-hydroxydecanoyl- ACP to E-(2)-decenoyl-ACP and then its isomerization to Z-(3)- decenoyl-ACP. Can catalyze the dehydratase reaction for beta- hydroxyacyl-ACPs with saturated chain lengths up to 16 0, being most active on intermediate chain length (By similarity) Aa30R_159 ENOG4108IPT Naphthoate synthase Aa30R_1591 ENOG4108R9Q Required for spatial organization of the terminus region of the chromosome (Ter macrodomain) during the cell cycle. Prevents early segregation of duplicated Ter macrodomains during cell division. Binds specifically to matS, which is a 13 bp signature motif repeated within the Ter macrodomain (By similarity) Aa30R_1595 ENOG4105WP7 tRNA pseudouridine synthase C Aa30R_1598 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family Aa30R_1607 ENOG4105CIY formyltetrahydrofolate deformylase Aa30R_1618 ENOG4108Z1B Cyclase dehydrase Aa30R_1619 ENOG4105VDB UPF0125 protein Aa30R_162 ENOG4105D4P Coproporphyrinogen iii oxidase Aa30R_1620 ENOG4105EZE Cupin 4 family protein Aa30R_1626 ENOG4108P1K Required for the translocation of lipopolysaccharide (LPS) from the inner membrane to the outer membrane (By similarity) Aa30R_1637 ENOG4107R0E Glycosyl transferase, family 2 Aa30R_1646 ENOG4105DQ6 Transposase Aa30R_1648 ENOG4105CI3 gtp-binding protein typa Aa30R_1650 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen Aa30R_1651 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) Aa30R_1669 ENOG4105K8R UPF0145 protein Aa30R_1670 ENOG4105CSA Coproporphyrinogen iii oxidase Aa30R_1679 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit Aa30R_1681 ENOG4105CG6 trap dicarboxylate transporter dctm subunit Aa30R_1691 ENOG4105VCC 30S ribosomal protein S21 Aa30R_1697 ENOG4107NPY receptor for the septal ring structure, may anchor it to the inner-membrane (By similarity) Aa30R_1702 ENOG4105C3G gtp-binding protein Aa30R_1707 ENOG4105E1P Modifies, by uridylylation or deuridylylation the PII (GlnB) regulatory protein (By similarity) Aa30R_1711 ENOG4105BZ4 penicillin-binding protein Aa30R_172 ENOG4105CNN ABC, transporter Aa30R_173 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator Aa30R_1739 ENOG4105C9S Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P) (By similarity) Aa30R_1740 ENOG4108ERU trap dicarboxylate transporter subunit DctP Aa30R_1753 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) Aa30R_1769 ENOG4105CEY Amp-dependent synthetase and ligase Aa30R_1779 ENOG4105Q4A inner membrane protein yciS Aa30R_1784 ENOG4105PE1 Receptor Aa30R_1791 ENOG4105DSS Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) Aa30R_1801 ENOG4105CC5 ABC transporter Aa30R_1803 ENOG41068P6 UPF0319 protein Aa30R_1806 ENOG4105EM2 membrane Aa30R_1817 ENOG41067MG lrgb family Aa30R_182 ENOG4105C0B DNA polymerase III (alpha subunit) Aa30R_1821 ENOG4105P9C Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process (By similarity) Aa30R_1852 ENOG4105C1B dTDP-glucose 4-6-dehydratase Aa30R_1855 ENOG4105CGK Exodeoxyribonuclease III Aa30R_1859 ENOG4108RT7 Glycosyl transferase, family 2 Aa30R_186 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase Aa30R_1866 ENOG4105K64 Glycosyl transferase, family 2 Aa30R_1871 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) Aa30R_1884 ENOG4105C4R Atp-dependent dna helicase Aa30R_189 ENOG4105EYA deoxyribonuclease Aa30R_1892 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein Aa30R_1900 ENOG4107WQX hydrogenase 4 membrane subunit Aa30R_1914 ENOG4105C5X domain protein Aa30R_1921 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) Aa30R_194 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) Aa30R_1946 ENOG4107QM1 Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) Aa30R_1952 ENOG4105K4U addiction module toxin, RelE StbE family Aa30R_1955 ENOG4105CFP Peptidase U32 Aa30R_1968 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator Aa30R_1976 ENOG4105D7K pfkb domain protein Aa30R_198 ENOG4105K6T rare lipoprotein A Aa30R_1983 ENOG4105DDI hemolysin-type calcium-binding region Aa30R_1986 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) Aa30R_1991 ENOG4108WPU DNA polymerase III subunit psi Aa30R_1993 ENOG4105DSY exodeoxyribonuclease V, gamma Aa30R_2002 ENOG4107YD3 Thioesterase Aa30R_2005 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii Aa30R_2034 ENOG4105QYV Membrane Aa30R_2039 ENOG4108J59 Extracellular solute-binding protein, family 5 Aa30R_2048 ENOG4105YK5 50S ribosomal protein L36 Aa30R_2049 ENOG4105NRA 50s ribosomal protein l31 type b Aa30R_2062 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) Aa30R_2069 ENOG4105CUZ uba thif-type nad fad binding protein Aa30R_2072 ENOG4108VPT UPF0234 protein Aa30R_2074 ENOG41062Z9 Membrane Aa30R_2090 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein Aa30R_2116 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) Aa30R_2122 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) Aa30R_214 ENOG4105E78 Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) Aa30R_220 ENOG4108V1T peptidylprolyl cis-trans isomerase Aa30R_231 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) Aa30R_234 ENOG4105MVE transcriptional regulator Aa30R_237 ENOG4105FB2 class II Aldolase Aa30R_241 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) Aa30R_246 ENOG4108WFC UPF0438 protein yifE Aa30R_251 ENOG4105DTZ bifunctional PTS system fructose-specific transporter subunit IIA HPr protein Aa30R_253 ENOG4105DM4 PTS System Aa30R_258 ENOG4105PM1 preprotein translocase subunit SecE Aa30R_265 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) Aa30R_267 ENOG4108RS6 transposase Aa30R_268 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal Aa30R_277 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) Aa30R_280 ENOG4107QP7 CoA-transferase subunit A Aa30R_287 ENOG4105DBV ornithine carbamoyltransferase Aa30R_297 ENOG4105CBM Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 (By similarity) Aa30R_3 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) Aa30R_309 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) Aa30R_313 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) Aa30R_324 ENOG4105CS6 Rhs element vgr protein Aa30R_342 ENOG4105XWI UPF0304 protein Aa30R_343 ENOG410903C (LipO)protein Aa30R_357 ENOG4105DAS pts system Aa30R_358 ENOG4105ETZ PTS System Aa30R_368 ENOG4105CXY transporter Aa30R_374 ENOG4105C1J atp-dependent rna helicase Aa30R_377 ENOG4105D3G Pseudouridine synthase Aa30R_383 ENOG4105C4R Atp-dependent dna helicase Aa30R_39 ENOG4108M1T Cytochrome c-type biogenesis protein Aa30R_390 ENOG4106W3N Aa30R_395 ENOG4106032 Glutathionylspermidine synthase Aa30R_396 ENOG4106032 Glutathionylspermidine synthase Aa30R_415 ENOG4105EMY transcriptional regulator Aa30R_421 ENOG4108TEB UPF0114 protein Aa30R_431 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) Aa30R_433 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) Aa30R_443 ENOG4107QWE )-transporter Aa30R_448 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) Aa30R_462 ENOG4105ED7 Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity) Aa30R_470 ENOG4105CDA abc transporter atp-binding protein Aa30R_474 ENOG4105WWK YheO domain protein Aa30R_478 ENOG4105C5Q Transcriptional regulator Aa30R_481 ENOG4108JJ9 ABC, transporter Aa30R_485 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase Aa30R_491 ENOG4105ECR NmrA family Aa30R_519 ENOG4105C2J ABC transporter Aa30R_538 ENOG4105CRP Part of the ABC transporter FtsEX involved in Aa30R_543 ENOG4105CE5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) Aa30R_561 ENOG4108ZDX Binds together with S18 to 16S ribosomal RNA (By similarity) Aa30R_57 ENOG4107ZVW dihydroneopterin aldolase Aa30R_570 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) Aa30R_58 ENOG4105CHQ Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella (By similarity) Aa30R_580 ENOG4105E07 UPF0149 protein Aa30R_583 ENOG4106SNF Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane Aa30R_585 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase Aa30R_592 ENOG4105BZS acriflavin resistance protein Aa30R_625 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) Aa30R_626 ENOG4105D49 3-dehydroquinate synthase Aa30R_63 ENOG4105CHM Aminotransferase Aa30R_636 ENOG4105M6F mutator MutT protein Aa30R_641 ENOG4105WV0 Glucose-6-phosphate 1-dehydrogenase (EC 1.1.1.49) Aa30R_643 ENOG41062MS nucleotidyltransferase substrate binding protein Aa30R_65 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) Aa30R_651 ENOG4105EMU Dehydrogenase Aa30R_659 ENOG4108JU6 CBS domain protein Aa30R_66 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) Aa30R_661 ENOG4105M15 transport protein ExbD Aa30R_684 ENOG4105D52 delta-aminolevulinic acid dehydratase Aa30R_689 ENOG4105VEJ Heat shock protein Aa30R_696 ENOG4108RNI 3'(2')5'-bisphosphate nucleotidase Aa30R_725 ENOG4105DFC had-superfamily hydrolase, subfamily ia, variant Aa30R_732 ENOG4105KQC Competence protein Aa30R_74 ENOG41090FY type IV pilus biogenesis stability protein PilW Aa30R_757 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) Aa30R_782 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) Aa30R_796 ENOG4107QP2 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) Aa30R_802 ENOG4107QVT Binding-protein-dependent transport systems, inner membrane component Aa30R_822 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) Aa30R_824 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) Aa30R_825 ENOG4107Y66 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) Aa30R_833 ENOG4108M6U Universal stress protein A Aa30R_836 ENOG4105E68 Sulfatase Aa30R_86 ENOG4108I6E Sulfatase Aa30R_867 ENOG4105MA0 exported protein Aa30R_868 ENOG4105CFU surface antigen Aa30R_870 ENOG4107T0K Adenylate cyclase Aa30R_885 ENOG4105CMG Carbohydrate kinase Aa30R_887 ENOG4105CNN ABC, transporter Aa30R_889 ENOG4105C2J ABC transporter Aa30R_903 ENOG4108IXY short-chain dehydrogenase reductase Aa30R_909 ENOG4105Y75 tpr repeat protein Aa30R_912 ENOG4105C1Y Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis (By similarity) Aa30R_913 ENOG4105EM7 Selenocysteine-specific translation elongation factor Aa30R_940 ENOG4108JA2 transcriptioN-repair coupling factor Aa30R_954 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) Aa30R_962 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) Aa30R_965 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) Aa30R_966 ENOG4105KUZ arsenate reductase Aa30R_978 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) Aa30R_982 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) Aa30R_988 ENOG4108HUF Transporter Aa30R_989 ENOG4105DIN metallophosphoesterase Aa30S_100 ENOG4105EFV Major head subunit Aa30S_1001 ENOG4107SC1 transglycosylase Aa30S_101 ENOG4108TVE i protein Aa30S_1014 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) Aa30S_102 ENOG4105ZS4 g protein Aa30S_1026 ENOG4108K6F triphosphoribosyl-dephospho-CoA synthase Aa30S_1043 ENOG4105C9I Chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB Aa30S_106 ENOG4106YXT transposase Aa30S_1066 ENOG4105C03 ribonuclease Aa30S_107 ENOG4105R8V Transcriptional regulator Aa30S_1073 ENOG4106BMH cytolethal distending toxin Aa30S_1078 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase Aa30S_108 ENOG4105M7P phage repressor Aa30S_1084 ENOG4106J39 exported protein Aa30S_1089 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) Aa30S_1090 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase Aa30S_1101 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) Aa30S_1108 ENOG4108EVY peptide transport periplasmic protein Aa30S_1114 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) Aa30S_1134 ENOG4105DDQ anthranilate synthase Aa30S_1138 ENOG4105D60 lipoprotein releasing system transmembrane protein Aa30S_114 ENOG4105C59 p-type ATPase Aa30S_1146 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) Aa30S_1150 ENOG4105XPH Ferredoxin Aa30S_1162 ENOG4105EG2 ABC transporter, permease Aa30S_1163 ENOG4105D56 permease protein Aa30S_1165 ENOG4108IJ9 (ABC) transporter Aa30S_1178 ENOG4107QI1 Mate efflux family protein Aa30S_1181 ENOG4107XNE ABC transporter, periplasmic molybdate-binding protein Aa30S_1184 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase Aa30S_1186 ENOG4105DN3 alpha-2-macroglobulin domain protein Aa30S_1193 ENOG4105DW5 Transcriptional regulator Aa30S_1198 ENOG4105CNT hydrolase family 2 Aa30S_1200 ENOG4108DBC nitroreductase Aa30S_1202 ENOG4105RHG Aa30S_1218 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH Aa30S_1231 ENOG4107XQ1 cobalamin (vitamin B12) biosynthesis CbiM protein Aa30S_1247 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) Aa30S_125 ENOG4107QQ0 gntp family Aa30S_1252 ENOG4105C8P )-transporter Aa30S_1266 ENOG4107QTR Required for nitrogen fixation. May be part of a membrane complex functioning as an intermediate in the electron transport to nitrogenase (By similarity) Aa30S_1274 ENOG4105DR5 peptidase Aa30S_1279 ENOG4107RNS bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase 3'-nucleotidase periplasmic Aa30S_128 ENOG4105C6Y Udp-glucose 6-dehydrogenase Aa30S_1301 ENOG4105DP9 ABC transporter Aa30S_1311 ENOG4108IIZ The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane Aa30S_1325 ENOG4105VT2 5-hydroxyisourate hydrolase Aa30S_135 ENOG4107QHF type ii secretion system protein e Aa30S_1352 ENOG4105KG7 Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) Aa30S_136 ENOG4105D7Q type ii secretion system Aa30S_1385 ENOG4107RTM 4-alpha-glucanotransferase (EC 2.4.1.25) Aa30S_1393 ENOG4105D07 Signal peptide peptidase, SppA Aa30S_1398 ENOG4105FE9 pseudouridine synthase Aa30S_1413 ENOG4105W4M Transport-associated protein Aa30S_1414 ENOG4105F55 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity) Aa30S_1415 ENOG41082RQ UPF0102 protein Aa30S_1416 ENOG4105E1C Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1A (PBP1a) (By similarity) Aa30S_1419 ENOG4105CEP NADH dehydrogenase Aa30S_1426 ENOG4105DP0 ferredoxin-NADP reductase Aa30S_1432 ENOG4105D2M Aldolase Aa30S_1439 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) Aa30S_1464 ENOG4108ESZ Glycogen debranching enzyme Aa30S_1467 ENOG4107QQN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) Aa30S_147 ENOG4105MZU cell filamentation protein Aa30S_1478 ENOG4105DUC Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division (By similarity) Aa30S_1479 ENOG4108TZV Membrane Aa30S_1482 ENOG4105DQ6 Transposase Aa30S_1496 ENOG4105CGF Aromatic amino acid aminotransferase Aa30S_1498 ENOG4105D0S secretion protein (HlyD Aa30S_1507 ENOG4107RNH Outer membrane receptor FepA Aa30S_1516 ENOG4108QBX (LipO)protein Aa30S_1521 ENOG4105D0M Protease HtpX homolog Aa30S_1528 ENOG4107QYG anthranilate phosphoribosyltransferase Aa30S_153 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase Aa30S_1537 ENOG4107QSA Oxaloacetate decarboxylase Aa30S_1546 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) Aa30S_1563 ENOG4105KB2 stringent starvation protein b Aa30S_1564 ENOG4107MKT Stringent starvation protein a Aa30S_1566 ENOG4105M00 molybdopterin converting factor, subunit 1 Aa30S_1585 ENOG4107QKA exodeoxyribonuclease V beta Aa30S_1590 ENOG4105VEQ Cold shock protein Aa30S_1597 ENOG4107TXD phosphoglycerate transport system transcriptional regulatory protein pgta Aa30S_1602 ENOG4108BPE -transporting atpase Aa30S_1610 ENOG4105CB5 ATP-dependent DNA helicase recG Aa30S_1611 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) Aa30S_1621 ENOG4107RM2 PTS IIA-like nitrogen-regulatory protein PtsN Aa30S_1627 ENOG4107PE3 Mammalian cell entry related domain protein Aa30S_1654 ENOG4105DFA alanine racemase domain protein Aa30S_1665 ENOG41083P1 competence protein ComEA helix-hairpin-helix repeat protein Aa30S_1678 ENOG4105XDZ Tripartite ATP-independent periplasmic transporter Aa30S_168 ENOG4105HF0 Membrane Aa30S_1688 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) Aa30S_1691 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) Aa30S_1702 ENOG4105DQ6 Transposase Aa30S_1707 ENOG4108YX9 iron--sulfur cluster insertion protein erpA Aa30S_1719 ENOG4105MN5 HAD-superfamily hydrolase subfamily IA variant 3 Aa30S_1723 ENOG4105CQ7 ATP-dependent helicase Aa30S_1725 ENOG4108VMM UPF0756 membrane protein Aa30S_1732 ENOG4105CE4 GlcNAc 6-P deacetylase Aa30S_1734 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) Aa30S_174 ENOG4108RVA ribokinase Aa30S_1760 ENOG4107QMP dna polymerase iii subunits gamma and tau Aa30S_1763 ENOG4105EJ9 Membrane Aa30S_1766 ENOG4105EGS Mechanosensitive ion channel Aa30S_1770 ENOG4105MHQ Low-potential electron donor to a number of redox enzymes (By similarity) Aa30S_1783 ENOG4105PE1 Receptor Aa30S_1784 ENOG4107RAN Peptidase, M16 Aa30S_1785 ENOG4107RAN Peptidase, M16 Aa30S_1788 ENOG4105DZ2 Transcriptional regulator Aa30S_1791 ENOG4105DFS Conserved Protein Aa30S_1794 ENOG4108MN8 Membrane Aa30S_1797 ENOG4105DIK (ABC) transporter Aa30S_1803 ENOG410901E Membrane Aa30S_1807 ENOG4108IUS Transketolase Aa30S_1814 ENOG4105C4Q deoxyguanosinetriphosphate triphosphohydrolase-like protein Aa30S_1816 ENOG4105VAW lrga family Aa30S_1818 ENOG4105C9B Cysteine desulfurase Aa30S_1820 ENOG4105DW0 Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity) Aa30S_1841 ENOG4105C29 acyl-CoA thioesterase Aa30S_1845 ENOG4105F3T (LipO)protein Aa30S_1846 ENOG4105EZX Catalyzes the phosphorylation of N-acetyl-D-glucosamine (GlcNAc) derived from cell-wall degradation, yielding GlcNAc-6-P (By similarity) Aa30S_1851 ENOG4105C1B dTDP-glucose 4-6-dehydratase Aa30S_1893 ENOG4105C8H hydrogenase maturation protein Hypf Aa30S_1900 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) Aa30S_1902 ENOG4105C47 NADH ubiquinone oxidoreductase 20 kda subunit Aa30S_1903 ENOG4105I6X formate hydrogenlyase maturation Aa30S_1910 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 Aa30S_1914 ENOG4105DIT ErfK YbiS YcfS YnhG family protein Aa30S_1917 ENOG4105H2K paraquat-inducible protein a Aa30S_1932 ENOG4105I7R Adenylate cyclase Aa30S_1959 ENOG4107QN8 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) Aa30S_1963 ENOG4105C0A alcohol dehydrogenase Aa30S_1968 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) Aa30S_197 ENOG4105DZ1 carboxypeptidase Aa30S_1977 ENOG4105CJK Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity) Aa30S_1980 ENOG4108JJA ABC, transporter Aa30S_2 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) Aa30S_2004 ENOG4105C4M (Ubiquinol oxidase) subunit I Aa30S_2019 ENOG4107ENK receptor Aa30S_2029 ENOG4105EAH synthase Aa30S_2038 ENOG4108J59 Extracellular solute-binding protein, family 5 Aa30S_2042 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component Aa30S_2044 ENOG4108JQ7 (ABC) transporter Aa30S_205 ENOG4107RGD Major Facilitator superfamily Aa30S_2055 ENOG4105C5I Dehydrogenase Aa30S_2059 ENOG4105MZU cell filamentation protein Aa30S_2071 ENOG4105EAC phosphoserine phosphatase Aa30S_2074 ENOG4105CJR Integral membrane protein (MviN Aa30S_208 ENOG4105CHR reductase Aa30S_2091 ENOG4105C0F tryptophanase EC 4.1.99.1 Aa30S_2097 ENOG4107S7E 1-acyl-sn-glycerol-3-phosphate acyltransferase Aa30S_211 ENOG4105C6B Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity) Aa30S_221 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) Aa30S_224 ENOG4105DWK Membrane Aa30S_225 ENOG4107XM3 UPF0442 protein Aa30S_228 ENOG4105RX8 Protein of unknown function (DUF1523) Aa30S_230 ENOG4107QRG dna polymerase iii Aa30S_249 ENOG4105C6R Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) Aa30S_252 ENOG4105DE4 1-phosphofructokinase Aa30S_279 ENOG4105CMU LysR family (Transcriptional regulator Aa30S_28 ENOG4105CBX hi0933 family Aa30S_29 ENOG4108DMF Cytochrome C biogenesis protein Aa30S_314 ENOG4108MJ5 VirK protein Aa30S_337 ENOG4105C0P Mg chelatase subunit ChlI Aa30S_338 ENOG4105PXI polysaccharide deacetylase Aa30S_34 ENOG4105D3S 4Fe-4S Ferredoxin, iron-sulfur binding domain protein Aa30S_350 ENOG4105CIC tryptophan-specific transport protein Aa30S_355 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) Aa30S_359 ENOG4105F3R pts system mannose fructose sorbose family iid Aa30S_360 ENOG410667J hydrolase Aa30S_366 ENOG4105CND Glycosyl transferase, family 2 Aa30S_386 ENOG4105C2M dna polymerase I Aa30S_40 ENOG4108M1T Cytochrome c-type biogenesis protein Aa30S_407 ENOG4105DEK Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) Aa30S_425 ENOG41063SR receptor Aa30S_426 ENOG4105CQ0 ABC transporter Aa30S_427 ENOG4105D0C transport protein Aa30S_439 ENOG4105DAF Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) Aa30S_446 ENOG4108RS6 transposase Aa30S_453 ENOG4105C5H ABC transporter Aa30S_454 ENOG4105EZI multiple antibiotic resistance (MarC)-related protein Aa30S_457 ENOG4105DFP Integrase Aa30S_46 ENOG4105CA5 Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes (By similarity) Aa30S_462 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate Aa30S_471 ENOG4108ZKU Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions (By similarity) Aa30S_472 ENOG4108ZAT Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE (By similarity) Aa30S_479 ENOG4105BZ1 (ABC) transporter Aa30S_492 ENOG4105D28 Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) Aa30S_497 ENOG4107S15 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) Aa30S_499 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) Aa30S_51 ENOG4105C6K Malic enzyme Aa30S_516 ENOG4105C87 Aminotransferase class I and II Aa30S_519 ENOG4105DFW ABC transporter Aa30S_520 ENOG4105C93 Xylose Isomerase Aa30S_524 ENOG4105DQ6 Transposase Aa30S_525 ENOG4105JIM Phosphatidylserine synthase Aa30S_531 ENOG4105PF3 O-Antigen polymerase Aa30S_532 ENOG4108EUD Lysophospholipase Aa30S_535 ENOG4105C7B Threonine dehydratase Aa30S_54 ENOG4105CGZ zinc metallopeptidase Aa30S_557 ENOG4105BZ1 (ABC) transporter Aa30S_568 ENOG4105C2N RNA methyltransferase TrmH family group 3 Aa30S_570 ENOG4105DFF Rod shape-determining protein mreb Aa30S_587 ENOG4105VZ9 UPF0235 protein Aa30S_594 ENOG41063M6 Cell Division Protein Aa30S_595 ENOG4105C25 Primosomal protein n' Aa30S_596 ENOG4108SEH involved in lipopolysaccharide biosynthesis Aa30S_617 ENOG4105D6S protein involved in catabolism of external DNA Aa30S_643 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) Aa30S_645 ENOG4105DBD Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity) Aa30S_672 ENOG4107QY8 reductase Aa30S_676 ENOG4105N1P Ferredoxin-type protein Aa30S_678 ENOG41063VX Inherit from COG: glutaredoxin-related protein Aa30S_696 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase Aa30S_719 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) Aa30S_735 ENOG4105MJ2 Competence protein Aa30S_738 ENOG4105CWM branched-chain amino acid transport system II carrier protein Aa30S_744 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits Aa30S_762 ENOG4108VVQ metallophosphoesterase Aa30S_764 ENOG41082K8 Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Interacts with IscS and stimulates its activity. Then, accepts a sulfur from IscS and transfers it in turn to TusD (By similarity) Aa30S_78 ENOG4105N21 Membrane Aa30S_786 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) Aa30S_798 ENOG4105FBT Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs (By similarity) Aa30S_80 ENOG4108KZ1 Mediates the interaction of DNA replication inititator protein DnaA with DNA polymerase subunit beta sliding clamp (dnaN). Stimulates hydrolysis of ATP-DnaA to ADP-DnaA, rendering DnaA inactive for reinititation, a process called regulatory inhibition of DnaA or RIDA (By similarity) Aa30S_800 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) Aa30S_807 ENOG4106S48 Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and or cell division Aa30S_829 ENOG4107QKV phosphomannomutase Aa30S_83 ENOG4105EIN peptidylprolyl cis-trans isomerase Aa30S_831 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) Aa30S_843 ENOG4107S2Z UPF0761 membrane protein Aa30S_846 ENOG4105D7A ATP-binding protein Aa30S_87 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) Aa30S_887 ENOG4105CNN ABC, transporter Aa30S_889 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator Aa30S_892 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) Aa30S_899 ENOG4105E7H involved in the assembly of LPS in the outer leaflet of the outer membrane. Determines N-hexane tolerance and is involved in outer membrane permeability. Essential for envelope biogenesis (By similarity) Aa30S_9 ENOG4105C6K Malic enzyme Aa30S_906 ENOG41069PW sigma-e factor negative regulatory protein Aa30S_93 ENOG4107H6E Aa30S_942 ENOG4106PMH Extracellular solute-binding protein family 3 Aa30S_944 ENOG4105DMR ABC, transporter Aa30S_955 ENOG4105CNI cell division protein FtsW Aa30S_957 ENOG4105DFU Cell wall formation (By similarity) Aa30S_963 ENOG4105CQC Prephenate dehydratase Aa30S_968 ENOG41087AY ADP-Ribose pyrophosphatase Aa30S_97 ENOG41067KA Domain of unknown function (DUF1834) Aa30S_978 ENOG4108VP9 Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane (By similarity) Aa30S_98 ENOG4105Y5J prophage protein Aa30S_994 ENOG4105DFP Integrase Aa31R_1 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) Aa31R_1000 ENOG4105CWG Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 (By similarity) Aa31R_1002 ENOG4105BZU Histidine kinase Aa31R_1003 ENOG4108HWV )-transporter Aa31R_1004 ENOG4105C2J ABC transporter Aa31R_1015 ENOG4105CHY citrate lyase, alpha Aa31R_102 ENOG4107QQ0 gntp family Aa31R_1026 ENOG4105E2D ec 3.2.1.52 Aa31R_1047 ENOG4105F27 Major Facilitator Aa31R_1054 ENOG4105C03 ribonuclease Aa31R_106 ENOG4105C1J atp-dependent rna helicase Aa31R_1062 ENOG4108TMH cytolethal distending toxin Aa31R_1077 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) Aa31R_112 ENOG4107QHF type ii secretion system protein e Aa31R_1129 ENOG4105CDU Replicative dna helicase Aa31R_1130 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) Aa31R_1143 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) Aa31R_1146 ENOG4105C4Y ABC transporter Aa31R_1157 ENOG4105D06 uba thif-type nad fad binding protein Aa31R_1168 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) Aa31R_1174 ENOG4105DN3 alpha-2-macroglobulin domain protein Aa31R_1175 ENOG4105HMI Membrane Aa31R_1187 ENOG41090BQ Glutaredoxin Aa31R_1190 ENOG4105D0Y UPF0227 protein Aa31R_1201 ENOG4105CAF HipA N-terminal domain protein Aa31R_1205 ENOG4108RMU ferritin dps family protein Aa31R_1222 ENOG4108JJB ABC transporter Aa31R_1224 ENOG4105CQS hydrogenase expression formation protein HypD Aa31R_1228 ENOG4106YXT transposase Aa31R_1244 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) Aa31R_1250 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) Aa31R_1265 ENOG4105CM4 permease protein Aa31R_1268 ENOG4107RNS bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase 3'-nucleotidase periplasmic Aa31R_1283 ENOG4107SRH Nad-dependent epimerase dehydratase Aa31R_1297 ENOG4105DDY UPF0142 protein ycaO Aa31R_1301 ENOG4108IIZ The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane Aa31R_1305 ENOG4105E2R ROK family Aa31R_1308 ENOG4105WMM Probably plays a role in a hydrogenase nickel cofactor insertion step (By similarity) Aa31R_1312 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) Aa31R_1338 ENOG4107QMH DNA methylase Aa31R_1347 ENOG4108IIE The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) Aa31R_1358 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) Aa31R_1363 ENOG4108EQH DNA internalization-related competence protein ComEC Rec2 Aa31R_1365 ENOG4105DJ0 Poly(A) Polymerase Aa31R_1371 ENOG4105PQ6 UPF0208 membrane protein Aa31R_1376 ENOG41061ZR Transcriptional regulator Aa31R_1383 ENOG4105EHE chorismate mutase- prephenate dehydrogenase Aa31R_139 ENOG4108HYK gCN5-related N-acetyltransferase Aa31R_1410 ENOG4105ERU peptidase Aa31R_1413 ENOG4105C22 threonyL-tRNA synthetase Aa31R_1421 ENOG4105D2M Aldolase Aa31R_1422 ENOG4105C6Q that is required for full activity and stability of the Y subunit. Could have a chaperone-like function for the proper and stable folding of Aa31R_1424 ENOG41090UW PTS System Aa31R_1425 ENOG4105DT3 PTS system, galactitol-specific IIc component Aa31R_1430 ENOG41067QG Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) Aa31R_1450 ENOG4108ZZ3 UPF0260 protein Aa31R_1453 ENOG4108ESZ Glycogen debranching enzyme Aa31R_1466 ENOG4105DUC Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division (By similarity) Aa31R_1471 ENOG4105DQ6 Transposase Aa31R_1481 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) Aa31R_1487 ENOG4105D0S secretion protein (HlyD Aa31R_1488 ENOG4105CJ1 ABC, transporter Aa31R_1491 ENOG4105EHG Permease protein Aa31R_1492 ENOG4105E0A ABC, transporter Aa31R_1498 ENOG4105E0A ABC, transporter Aa31R_1499 ENOG4105EHG Permease protein Aa31R_1507 ENOG4108ZUF This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) Aa31R_151 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator Aa31R_1515 ENOG4105CRQ synthase (Component I) Aa31R_1516 ENOG4105DDQ anthranilate synthase Aa31R_1531 ENOG4108MVK Receptor Aa31R_1539 ENOG4105CA9 Pyruvate kinase Aa31R_1541 ENOG41061GT Aldolase Aa31R_1549 ENOG4105DKT Transcriptional regulator Aa31R_1556 ENOG4108ZAF Molybdopterin Aa31R_1564 ENOG4105CUW cytochrome C-TYPE protein Aa31R_1567 ENOG4107QPK )-transporter Aa31R_1579 ENOG4105DAN ATP-dependent protease Aa31R_1585 ENOG4105EXF Zn-ribbon-containing, possibly nucleic-acid-binding protein Aa31R_159 ENOG4108KU3 Integrase Aa31R_1598 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) Aa31R_1601 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) Aa31R_1628 ENOG4105KZW UPF0381 protein Aa31R_1634 ENOG4105DQ6 Transposase Aa31R_1644 ENOG4105DFA alanine racemase domain protein Aa31R_1662 ENOG4105S10 periplasmic binding protein Aa31R_1665 ENOG4105DMW Dehydrogenase reductase Aa31R_1668 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit Aa31R_1676 ENOG4105CHH sulfate transporter Aa31R_1679 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) Aa31R_1700 ENOG4105BZ4 penicillin-binding protein Aa31R_1706 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) Aa31R_1714 ENOG4105M08 Membrane Aa31R_1730 ENOG4108MX5 Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses (By similarity) Aa31R_1752 ENOG4105NWR lipid A biosynthesis (Kdo)2-(Lauroyl)-lipid IVA acyltransferase Aa31R_1755 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase Aa31R_1759 ENOG4105EV9 Alpha Beta Hydrolase Aa31R_1769 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) Aa31R_1770 ENOG4105CAT Cytidine monophosphate kinase Aa31R_1775 ENOG4108UMN azlc family Aa31R_1780 ENOG4105BZK Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair (By similarity) Aa31R_1789 ENOG41068P6 UPF0319 protein Aa31R_1801 ENOG4105C5H ABC transporter Aa31R_1802 ENOG4105C4Q deoxyguanosinetriphosphate triphosphohydrolase-like protein Aa31R_1818 ENOG4105CA0 peroxidase Aa31R_1820 ENOG4105CEY Amp-dependent synthetase and ligase Aa31R_1827 ENOG4108JJ9 ABC, transporter Aa31R_183 ENOG4105DZ1 carboxypeptidase Aa31R_1854 ENOG4105MFV ABC-2 type transporter Aa31R_1858 ENOG4105C1B dTDP-glucose 4-6-dehydratase Aa31R_1860 ENOG4108RYC glycosyltransferase Aa31R_1868 ENOG41080C8 DUF218 domain Aa31R_1871 ENOG4105C6Z Gluconate Aa31R_1881 ENOG4105C8H hydrogenase maturation protein Hypf Aa31R_1883 ENOG4108JPZ Monovalent cation H antiporter subunit D Aa31R_1885 ENOG4105D65 subunit l Aa31R_1892 ENOG4108MG9 hydrogenase 3 maturation protease Aa31R_1893 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) Aa31R_1894 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) Aa31R_1896 ENOG4105CMV Succinyl-CoA synthetase subunit beta Aa31R_1911 ENOG4105D38 putrescine abc transporter Aa31R_1912 ENOG4107RUE extracellular solute-binding protein family 1 Aa31R_1925 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate Aa31R_1936 ENOG4108UMW Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) Aa31R_1937 ENOG4107RZZ dna polymerase iii epsilon subunit Aa31R_1949 ENOG4107RAB Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) Aa31R_1954 ENOG4105C2J ABC transporter Aa31R_1957 ENOG4107RJ5 oxidoreductase Aa31R_1963 ENOG4105D7K pfkb domain protein Aa31R_1965 ENOG4108HRG Involved in the cleavage of the C1-C2 bond of 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (THcHDO) to yield 5-deoxy- glucuronate (5DG) (By similarity) Aa31R_1967 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) Aa31R_1976 ENOG4105C5Y PTS System Aa31R_1977 ENOG4105D8J Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity) Aa31R_1984 ENOG4105KCK Peptidoglycan-associated lipoprotein Aa31R_1985 ENOG4107R6Y Involved in the TonB-independent uptake of proteins (By similarity) Aa31R_2000 ENOG4108TIT dATP pyrophosphohydrolase Aa31R_2008 ENOG4107ENK receptor Aa31R_2010 ENOG4105DH5 Responsible for the end-turnover of tRNA specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A). Also appears to be involved in tRNA biosynthesis (By similarity) Aa31R_2011 ENOG4105D3Y Na H antiporter Aa31R_2013 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) Aa31R_2015 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family Aa31R_2021 ENOG4105QYV Membrane Aa31R_2035 ENOG4108URH decarboxylase Aa31R_2040 ENOG4105EI2 Pseudouridine synthase Aa31R_2043 ENOG4105C28 cystathionine Aa31R_2044 ENOG4105EJX conjugal transfer ATPase Aa31R_2052 ENOG4105DFU Cell wall formation (By similarity) Aa31R_2058 ENOG4105EAC phosphoserine phosphatase Aa31R_2074 ENOG4108UBT opacity-associated protein Aa31R_2078 ENOG4105C0F tryptophanase EC 4.1.99.1 Aa31R_2080 ENOG4105E0U tyrosine-specific transport protein Aa31R_2085 ENOG4107TZ2 Cell division protein that is required for growth during stress conditions. May be involved in protecting or stabilizing the divisomal assembly under conditions of stress (By similarity) Aa31R_21 ENOG4107QMH DNA methylase Aa31R_215 ENOG4105F8V Hydrolase, tatD family Aa31R_216 ENOG4107QRG dna polymerase iii Aa31R_217 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) Aa31R_218 ENOG4105HHA aminodeoxychorismate lyase Aa31R_219 ENOG4108YZA Nitrogen regulatory protein pii Aa31R_261 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) Aa31R_265 ENOG4107QP7 CoA-transferase subunit A Aa31R_275 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) Aa31R_277 ENOG4108VVK transcriptional Regulator, AsnC Aa31R_294 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase Aa31R_297 ENOG4105D01 (LipO)protein Aa31R_327 ENOG4107QSU Phosphoglucomutase phosphomannomutase alpha beta alpha domain Aa31R_381 ENOG4105XA0 heptosyltransferase ii Aa31R_386 ENOG4108BGM Quinol dehydrogenase periplasmic component Aa31R_393 ENOG4105DEK Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) Aa31R_411 ENOG4105E98 transcriptional regulator DeoR family Aa31R_419 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) Aa31R_42 ENOG4108ZKK Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH (By similarity) Aa31R_424 ENOG4105D7M Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) Aa31R_429 ENOG4107QWE )-transporter Aa31R_430 ENOG4108HPI phosphatidate Cytidylyltransferase Aa31R_439 ENOG4105C5H ABC transporter Aa31R_449 ENOG4105ED7 Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity) Aa31R_450 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate Aa31R_462 ENOG4108V1T peptidylprolyl cis-trans isomerase Aa31R_467 ENOG4105BZ1 (ABC) transporter Aa31R_468 ENOG4108JJ9 ABC, transporter Aa31R_469 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter Aa31R_47 ENOG4105C2C drug resistance transporter, Bcr CflA Aa31R_470 ENOG4107YZP Rhodanese domain protein Aa31R_498 ENOG4105ETZ PTS System Aa31R_499 ENOG4105DAS pts system Aa31R_503 ENOG4105DFD Na H antiporter Aa31R_504 ENOG4105C87 Aminotransferase class I and II Aa31R_505 ENOG4108HWW ABC transporter Aa31R_51 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) Aa31R_513 ENOG4105JIM Phosphatidylserine synthase Aa31R_523 ENOG4105C7B Threonine dehydratase Aa31R_524 ENOG4105C7B Threonine dehydratase Aa31R_533 ENOG4106NZV Responsible for synthesis of pseudouridine from uracil- 13 in transfer RNAs (By similarity) Aa31R_552 ENOG4105K9Q Binds to the 23S rRNA (By similarity) Aa31R_572 ENOG4105C34 Pseudouridine synthase Aa31R_577 ENOG4108VIA integral membrane protein Aa31R_579 ENOG4108BSC Methyltransferase Aa31R_603 ENOG4105YP7 UPF0270 protein Aa31R_61 ENOG4105C05 Multifunctional regulator of fatty acid metabolism (By similarity) Aa31R_615 ENOG4105DFE Dna adenine methylase Aa31R_627 ENOG4105DJF DNA polymerase III, delta' subunit Aa31R_634 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) Aa31R_635 ENOG4105DBD Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity) Aa31R_638 ENOG41075W9 High frequency lysogenization protein HflD homolog Aa31R_64 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) Aa31R_643 ENOG4107QPD alcohol dehydrogenase Aa31R_652 ENOG41067XB TonB family Aa31R_676 ENOG4105X8U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity) Aa31R_680 ENOG4107Y3D HAD-superfamily hydrolase subfamily IA variant 3 Aa31R_684 ENOG4105EPD Oligopeptide transporter, Opt family Aa31R_687 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase Aa31R_697 ENOG4105C2D reductase Aa31R_719 ENOG4105CXB phosphoribosylaminoimidazole synthetase Aa31R_723 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) Aa31R_729 ENOG4105CWM branched-chain amino acid transport system II carrier protein Aa31R_748 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) Aa31R_75 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) Aa31R_751 ENOG4108RS6 transposase Aa31R_752 ENOG4105E0U tyrosine-specific transport protein Aa31R_754 ENOG4107VZS Nicotinamide-nucleotide adenylyltransferase Aa31R_769 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) Aa31R_772 ENOG4105DQ6 Transposase Aa31R_788 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) Aa31R_80 ENOG4105C2W permease Aa31R_819 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) Aa31R_83 ENOG4105D9M gamma-glutamylcysteine synthetase Aa31R_836 ENOG4105EQ2 LysR family Transcriptional regulator Aa31R_838 ENOG4105CPC Aldo Keto reductase Aa31R_839 ENOG4105EBR Carboxylesterase Aa31R_842 ENOG4105EQ2 LysR family Transcriptional regulator Aa31R_844 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) Aa31R_845 ENOG4105MVE transcriptional regulator Aa31R_86 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) Aa31R_867 ENOG4105BZM domain protein Aa31R_87 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) Aa31R_885 ENOG4105R3P Inner membrane protein yagU Aa31R_895 ENOG4105EMN RNA polymerase sigma factor Aa31R_898 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) Aa31R_905 ENOG4105C8J )-transporter Aa31R_923 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) Aa31R_927 ENOG4108JA2 transcriptioN-repair coupling factor Aa31R_936 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) Aa31R_939 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) Aa31R_94 ENOG4108R96 Methyltransferase, YaeB family Aa31R_942 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) Aa31R_949 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) Aa31R_978 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) Aa31R_996 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) Aa31S_10 ENOG4105C0B DNA polymerase III (alpha subunit) Aa31S_1005 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase Aa31S_1009 ENOG4108JQB penicillin-binding protein 1C Aa31S_1015 ENOG41064BZ L-xylulose 5-phosphate 3-epimerase Aa31S_1017 ENOG4105E0U tyrosine-specific transport protein Aa31S_102 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity Aa31S_1040 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH Aa31S_1042 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) Aa31S_1048 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) Aa31S_107 ENOG4105CMU LysR family (Transcriptional regulator Aa31S_1079 ENOG4105EZ6 Catalyzes the 2'-O-methylation at nucleotide C2498 in 23S rRNA (By similarity) Aa31S_1081 ENOG4105CM2 brancheD-chain amino acid aminotransferase Aa31S_1084 ENOG410682Y Regulates arginine biosynthesis genes (By similarity) Aa31S_1099 ENOG4105DHS permease protein Aa31S_11 ENOG4108IQE Amp-dependent synthetase and ligase Aa31S_110 ENOG4107QNJ CoA-transferase subunit B Aa31S_111 ENOG4105CRW Short chain fatty acid transporter Aa31S_1113 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) Aa31S_1115 ENOG4105CDH Citrulline--aspartate ligase Aa31S_1117 ENOG4105C8A Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity) Aa31S_112 ENOG4105CHU acetyl-coa acetyltransferase Aa31S_1120 ENOG4105CE6 Adenylation and deadenylation of glutamate--ammonia ligase (By similarity) Aa31S_1124 ENOG4105DP9 ABC transporter Aa31S_1125 ENOG4106SMU thiamine transporter membrane protein Aa31S_1136 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) Aa31S_115 ENOG4105C5B carbamate kinase Aa31S_1167 ENOG4105CEE C4-dicarboxylate transporter Aa31S_1171 ENOG4107QMH DNA methylase Aa31S_1173 ENOG4105C0D helicase Aa31S_1195 ENOG4105BZ1 (ABC) transporter Aa31S_1199 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase Aa31S_1202 ENOG4108DNC Involved in acetate metabolism (By similarity) Aa31S_1203 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) Aa31S_1208 ENOG4107QQN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) Aa31S_1213 ENOG4107QN2 dihydrolipoyl dehydrogenase Aa31S_1214 ENOG41069NU Nitroreductase Aa31S_1225 ENOG4105DWV Homoserine O-trans-acetylase Aa31S_1230 ENOG4105KJP alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen Aa31S_1231 ENOG4107QIV Cytochrome c biogenesis protein Aa31S_1251 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) Aa31S_1258 ENOG4107WTH Galactitol-1-phosphate dehydrogenase Aa31S_1266 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) Aa31S_127 ENOG4105KJF protein tyrosine phosphatase Aa31S_1280 ENOG4105DJY efflux transporter, rnd family, mfp subunit Aa31S_1284 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) Aa31S_1288 ENOG4107QQN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) Aa31S_129 ENOG4108YZY peptidylprolyl cis-trans isomerase Aa31S_1293 ENOG4105GHU Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity (By similarity) Aa31S_1294 ENOG4105CEY Amp-dependent synthetase and ligase Aa31S_1302 ENOG4105DQ6 Transposase Aa31S_1305 ENOG41090A1 ferritin Aa31S_1308 ENOG4105DS0 Transcriptional regulator, Crp Fnr family Aa31S_1312 ENOG4105DB7 PHP domain protein Aa31S_1327 ENOG4105E0A ABC, transporter Aa31S_1330 ENOG4105S10 periplasmic binding protein Aa31S_1342 ENOG4105C2X Arabinose 5-phosphate isomerase Aa31S_1357 ENOG4105D9Q decarboxylase (Beta subunit) Aa31S_1359 ENOG4108MVK Receptor Aa31S_1366 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) Aa31S_1412 ENOG4105DR9 pseudouridine synthase Aa31S_1419 ENOG4106JDA Phosphoglycerate transport regulatory protein PGTC Aa31S_1423 ENOG4105F7M Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit (By similarity) Aa31S_1425 ENOG4108SAU DNA-binding protein H-ns Aa31S_1426 ENOG4107S6Z Na H antiporter Aa31S_1429 ENOG4105CB5 ATP-dependent DNA helicase recG Aa31S_1448 ENOG4105E3I toluene tolerance Aa31S_1450 ENOG4105VFK BolA family Aa31S_1455 ENOG4107R0E Glycosyl transferase, family 2 Aa31S_146 ENOG4105C0P Mg chelatase subunit ChlI Aa31S_1463 ENOG4105DQ6 Transposase Aa31S_1470 ENOG4107EG0 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) Aa31S_1476 ENOG4105CFH Aspartokinase Aa31S_1482 ENOG4105EPW hflc protein Aa31S_1485 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) Aa31S_1489 ENOG4108JQ1 Dehydrogenase Aa31S_1496 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit Aa31S_1506 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) Aa31S_1507 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) Aa31S_154 ENOG4105CS6 Rhs element vgr protein Aa31S_1553 ENOG4105CE4 GlcNAc 6-P deacetylase Aa31S_1589 ENOG4107CDU Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated (By similarity) Aa31S_1592 ENOG41090R7 Ferric uptake Aa31S_1593 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) Aa31S_1602 ENOG4108MJ5 VirK protein Aa31S_1603 ENOG4105PE1 Receptor Aa31S_1608 ENOG4105DSS Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) Aa31S_1618 ENOG4105CC5 ABC transporter Aa31S_1642 ENOG4105DYS nad(p)h dehydrogenase (quinone) Aa31S_1653 ENOG41072GX Peptidase M22 Glycoprotease Aa31S_1662 ENOG4105XTM Inherit from NOG: Mn2 dependent serine threonine protein kinase Aa31S_167 ENOG4105C0P Mg chelatase subunit ChlI Aa31S_1688 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) Aa31S_169 ENOG41063SB peptidase Aa31S_1690 ENOG4105CVE Lytic murein transglycosylase Aa31S_1692 ENOG4108RJ9 Glycosyl transferase, family 2 Aa31S_1705 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) Aa31S_171 ENOG4105DKJ Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) Aa31S_1713 ENOG4108MFN small subunit of hydrogenase-3, iron-sulfur protein (part of formate hydrogenlyase (FHL) complex) Aa31S_1729 ENOG4105C7S Dehydrogenase Aa31S_1730 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 Aa31S_1735 ENOG4105CN1 protease Aa31S_1736 ENOG41073DY may be a structural element that influences the osmotic activation of ProP at a post-translational level (By similarity) Aa31S_1738 ENOG4105DY2 Paraquat-inducible protein b Aa31S_1744 ENOG4107T42 This enzyme scavenge exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis (By similarity) Aa31S_1749 ENOG4105CNU cell division protein FtsK Aa31S_1753 ENOG4107IX6 phosphate transport regulator Aa31S_1757 ENOG4108AD6 Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein (By similarity) Aa31S_1764 ENOG4107QM1 Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) Aa31S_1766 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase Aa31S_1774 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) Aa31S_1775 ENOG4105CIH Imidazole acetol-phosphate transaminase Aa31S_1778 ENOG4105VIE preprotein translocase, subunit YajC Aa31S_1783 ENOG4105C0A alcohol dehydrogenase Aa31S_1790 ENOG4105CXY transporter Aa31S_1799 ENOG4105C42 Type I secretion membrane fusion protein (HlyD Aa31S_1806 ENOG4105C5Y PTS System Aa31S_1810 ENOG4105KEG ribosomal-protein-alanine acetyltransferase Aa31S_1811 ENOG4105DSY exodeoxyribonuclease V, gamma Aa31S_1819 ENOG4105E02 MotA TolQ exbB proton channel Aa31S_1834 ENOG4105C9M aspartyl-trna synthetase Aa31S_184 ENOG4105C31 Tryptophanyl-tRNA synthetase Aa31S_1840 ENOG4108UYE Lactoylglutathione lyase Aa31S_1853 ENOG4105QYV Membrane Aa31S_1857 ENOG4108J59 Extracellular solute-binding protein, family 5 Aa31S_1861 ENOG4105C3U ABC transporter Aa31S_1863 ENOG41065U4 response regulator Aa31S_1868 ENOG4105MGM doxx family Aa31S_1869 ENOG4105C03 ribonuclease Aa31S_187 ENOG4105DAS pts system Aa31S_1872 ENOG4105K63 Thioredoxin Aa31S_1878 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) Aa31S_1920 ENOG4105TMB Formate nitrite transporter Aa31S_1925 ENOG4105CTQ phosphohexokinase Aa31S_1927 ENOG41076HS cation diffusion facilitator family transporter Aa31S_1936 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) Aa31S_1942 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) Aa31S_1956 ENOG41088T4 Helicase IV Aa31S_196 ENOG4105CND Glycosyl transferase, family 2 Aa31S_1971 ENOG4105DA4 cytochrome c-type biogenesis protein Aa31S_1996 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) Aa31S_2011 ENOG4105EJQ L-serine dehydratase Aa31S_2036 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase Aa31S_2041 ENOG4108UGV hypoxanthine phosphoribosyltransferase Aa31S_2042 ENOG4105BZW Glycerate kinase Aa31S_2044 ENOG4107VHA regulatoR Aa31S_2054 ENOG4107QHF type ii secretion system protein e Aa31S_2060 ENOG4105BZG amino acid carrier protein Aa31S_2064 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) Aa31S_2079 ENOG4108IPT Naphthoate synthase Aa31S_2084 ENOG4105ZR3 A GTPase-activating protein (GAP) that modifies Der EngA GTPase function. May play a role in ribosome biogenesis (By similarity) Aa31S_2089 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) Aa31S_2091 ENOG4105C2J ABC transporter Aa31S_21 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) Aa31S_238 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) Aa31S_245 ENOG4105DTR rard protein Aa31S_249 ENOG4105CGY Dna recombination protein Aa31S_253 ENOG4105EBW Rhomboid-type serine protease that catalyzes intramembrane proteolysis (By similarity) Aa31S_264 ENOG4105DZP Membrane-associated zinc metalloprotease Aa31S_28 ENOG4105CNI cell division protein FtsW Aa31S_287 ENOG4105IYK transposase Aa31S_297 ENOG4105CJP fad dependent oxidoreductase Aa31S_314 ENOG4105IX2 One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA (By similarity) Aa31S_32 ENOG4105C1J atp-dependent rna helicase Aa31S_323 ENOG4105D28 Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) Aa31S_345 ENOG4105T16 Transcriptional regulator (AraC family) Aa31S_352 ENOG4105CMG Carbohydrate kinase Aa31S_358 ENOG41083KI ribonuclease, T2 Aa31S_360 ENOG4105D2N Aldolase Aa31S_362 ENOG4108EUD Lysophospholipase Aa31S_37 ENOG4105CHR reductase Aa31S_377 ENOG4108UM1 dedA family Aa31S_38 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase Aa31S_385 ENOG4105DKP glycosyl transferase, family 9 Aa31S_387 ENOG4105E7U AraC family transcriptional regulator Aa31S_402 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) Aa31S_412 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase Aa31S_416 ENOG4105E0M Sulfatase Aa31S_417 ENOG4108RCM Nitroreductase Aa31S_42 ENOG4105FCQ metal-binding, possibly nucleic acid-binding protein Aa31S_422 ENOG4105BZS acriflavin resistance protein Aa31S_424 ENOG4105Y7M Transcriptional regulator, TetR family Aa31S_439 ENOG4105M7P phage repressor Aa31S_44 ENOG41090JN Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) Aa31S_442 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase Aa31S_444 ENOG4105EC0 Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions (By similarity) Aa31S_446 ENOG4107RYR Transcriptional regulator, Crp Fnr family Aa31S_459 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) Aa31S_466 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving Aa31S_472 ENOG4105WV0 Glucose-6-phosphate 1-dehydrogenase (EC 1.1.1.49) Aa31S_486 ENOG4107QPD alcohol dehydrogenase Aa31S_490 ENOG4106KVJ cytochrome C assembly protein Aa31S_506 ENOG4105QAX Iron-sulfur Aa31S_568 ENOG4107RUK Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins (By similarity) Aa31S_573 ENOG4108RS6 transposase Aa31S_578 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) Aa31S_584 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) Aa31S_594 ENOG4108VVQ metallophosphoesterase Aa31S_623 ENOG4105DSJ YicC domain protein Aa31S_627 ENOG4105FBT Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs (By similarity) Aa31S_629 ENOG4105FBT Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs (By similarity) Aa31S_631 ENOG4107QVT Binding-protein-dependent transport systems, inner membrane component Aa31S_635 ENOG4105CEN a g-specific adenine glycosylase Aa31S_637 ENOG4106S48 Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and or cell division Aa31S_638 ENOG4105IEY (LipO)protein Aa31S_644 ENOG4106I92 NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) Aa31S_647 ENOG4105D26 NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. The first step is catalyzed by NqrF, which accepts electrons from NADH and reduces ubiquinone-1 to ubisemiquinone by a one-electron transfer pathway (By similarity) Aa31S_658 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase Aa31S_660 ENOG4105VM8 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity) Aa31S_674 ENOG4105K5B UPF0225 protein Aa31S_695 ENOG4105C9X ppx gppa phosphatase Aa31S_699 ENOG4107T0K Adenylate cyclase Aa31S_700 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) Aa31S_702 ENOG4105ECF c-methyltransferase Aa31S_703 ENOG410601J HemY protein Aa31S_704 ENOG4105EX9 Membrane Aa31S_708 ENOG4108RRZ Transcription elongation factor GreB Aa31S_713 ENOG4105BZM domain protein Aa31S_714 ENOG4105CMG Carbohydrate kinase Aa31S_724 ENOG4105XQ6 frataxin-like protein Aa31S_728 ENOG4108R3E Dna-3-methyladenine glycosylase i Aa31S_732 ENOG4108IXY short-chain dehydrogenase reductase Aa31S_734 ENOG4105WMJ Positive regulator of sigma E, RseC MucC Aa31S_735 ENOG4105VQK sigma E regulatory protein, MucB RseB Aa31S_765 ENOG4105DMR ABC, transporter Aa31S_768 ENOG4108V6E Cell division protein mraZ Aa31S_798 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) Aa31S_805 ENOG4105E0A ABC, transporter Aa31S_806 ENOG4108IHU transport system permease protein Aa31S_809 ENOG4105DIN metallophosphoesterase Aa31S_822 ENOG4107SC1 transglycosylase Aa31S_838 ENOG4105C2J ABC transporter Aa31S_839 ENOG4105EMA Periplasmic binding protein LacI transcriptional regulator Aa31S_840 ENOG41060NJ transcriptional regulator Aa31S_853 ENOG4108JU5 Magnesium and cobalt efflux protein Aa31S_866 ENOG4108Z4V iron-sulfur cluster assembly Aa31S_87 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) Aa31S_873 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) Aa31S_874 ENOG4107RCV ABC transporter, permease Aa31S_884 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis Aa31S_899 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase Aa31S_918 ENOG4105EEI dihydropteroate synthase Aa31S_919 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) Aa31S_92 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) Aa31S_93 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) Aa31S_930 ENOG4105CM6 amino acid regulated cytosolic protein Aa31S_937 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) Aa31S_95 ENOG4108RS6 transposase Aa31S_950 ENOG4105DGW oligopeptidase A Aa31S_980 ENOG4107RCV ABC transporter, permease Aa31S_981 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) Aa31S_983 ENOG4105EG2 ABC transporter, permease Aa31S_99 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) Aa31S_994 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) Aa4R_1001 ENOG4105DT3 PTS system, galactitol-specific IIc component Aa4R_1002 ENOG4107WTH Galactitol-1-phosphate dehydrogenase Aa4R_1007 ENOG4107QTG Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity) Aa4R_1011 ENOG4105DWU Membrane Aa4R_1012 ENOG4108W1A pseudouridine synthase Aa4R_1023 ENOG4105DJY efflux transporter, rnd family, mfp subunit Aa4R_1028 ENOG4108ESZ Glycogen debranching enzyme Aa4R_1030 ENOG4105CXW Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) Aa4R_1031 ENOG4107QQN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) Aa4R_1035 ENOG41061WM D-Alanyl-D-Alanine Aa4R_1037 ENOG4105CEY Amp-dependent synthetase and ligase Aa4R_1039 ENOG4105DUC Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division (By similarity) Aa4R_1040 ENOG4108TZV Membrane Aa4R_1055 ENOG4105CD8 aminopeptidase N Aa4R_1056 ENOG4105CGF Aromatic amino acid aminotransferase Aa4R_1066 ENOG4107RNH Outer membrane receptor FepA Aa4R_1067 ENOG4107RNH Outer membrane receptor FepA Aa4R_1082 ENOG4105CRQ synthase (Component I) Aa4R_1093 ENOG4107QSA Oxaloacetate decarboxylase Aa4R_1119 ENOG41061GT Aldolase Aa4R_1120 ENOG4105D4B ABC, transporter Aa4R_1122 ENOG41071MT Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Probably responsible for the translocation of the substrate across the membrane Aa4R_1123 ENOG4105C2J ABC transporter Aa4R_1129 ENOG4105DAG ROK family Aa4R_1130 ENOG4105C5S asparaginyl-tRNA synthetase Aa4R_1140 ENOG4105EQ6 Hydrolyzes dipeptides containing N-terminal aspartate residues. May play a role in allowing the cell to use peptide aspartate to spare carbon otherwise required for the synthesis of the aspartate family of amino acids (By similarity) Aa4R_1149 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) Aa4R_1154 ENOG4107QKA exodeoxyribonuclease V beta Aa4R_1157 ENOG4105DAN ATP-dependent protease Aa4R_1171 ENOG4108IJ6 ABC transporter Aa4R_1173 ENOG4108BPE -transporting atpase Aa4R_1177 ENOG4108SAU DNA-binding protein H-ns Aa4R_1178 ENOG4107S6Z Na H antiporter Aa4R_1180 ENOG4105VEI Removes the pyruvyl group from chorismate, with concomitant aromatization of the ring, to provide 4- hydroxybenzoate (4HB) for the ubiquinone pathway (By similarity) Aa4R_1181 ENOG4105CB5 ATP-dependent DNA helicase recG Aa4R_1182 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) Aa4R_1184 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) Aa4R_1185 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase Aa4R_1189 ENOG4105EZE Cupin 4 family protein Aa4R_1197 ENOG4105CY3 ABC transporter, permease Aa4R_1201 ENOG4105VFK BolA family Aa4R_1207 ENOG4105KZW UPF0381 protein Aa4R_1208 ENOG4105CKF membrane protein involved in aromatic hydrocarbon degradation Aa4R_1214 ENOG4105C5F glutamine synthetase Aa4R_1217 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen Aa4R_1232 ENOG4105EPW hflc protein Aa4R_1235 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) Aa4R_1237 ENOG4105CSA Coproporphyrinogen iii oxidase Aa4R_1239 ENOG4108JQ1 Dehydrogenase Aa4R_1241 ENOG4105S10 periplasmic binding protein Aa4R_1248 ENOG4105CG6 trap dicarboxylate transporter dctm subunit Aa4R_1254 ENOG4105CHH sulfate transporter Aa4R_1256 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) Aa4R_1271 ENOG4105DQ6 Transposase Aa4R_1275 ENOG4105IYK transposase Aa4R_1276 ENOG4107UCJ Catalyzes the synthesis of activated sulfate (By similarity) Aa4R_1278 ENOG4105DQ6 Transposase Aa4R_1279 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) Aa4R_1288 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) Aa4R_1289 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) Aa4R_1299 ENOG4105C28 cystathionine Aa4R_1304 ENOG4108TMH cytolethal distending toxin Aa4R_1323 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) Aa4R_1324 ENOG4105F27 Major Facilitator Aa4R_1330 ENOG4107RCV ABC transporter, permease Aa4R_1339 ENOG4108SWN Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA (By similarity) Aa4R_1341 ENOG4108ZIT Ferredoxin, 2FE-2S Aa4R_1343 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) Aa4R_1345 ENOG4105E2D ec 3.2.1.52 Aa4R_1351 ENOG4108JU5 Magnesium and cobalt efflux protein Aa4R_1353 ENOG4105DUA (citrate (pro-3S)-lyase ligase Aa4R_1357 ENOG4108K6F triphosphoribosyl-dephospho-CoA synthase Aa4R_1361 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) Aa4R_1363 ENOG4105F0Z galactose-1-phosphate uridylyltransferase Aa4R_1367 ENOG4105C2J ABC transporter Aa4R_1369 ENOG4105BZU Histidine kinase Aa4R_137 ENOG4105D7Q type ii secretion system Aa4R_1373 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ Aa4R_138 ENOG4107QHF type ii secretion system protein e Aa4R_1381 ENOG4105K9H YciI-like protein Aa4R_1382 ENOG4107SC1 transglycosylase Aa4R_1384 ENOG4108VKV Monofunctional biosynthetic peptidoglycan transglycosylase Aa4R_1392 ENOG4105DIN metallophosphoesterase Aa4R_1393 ENOG4108HUF Transporter Aa4R_1394 ENOG4105DQ5 transport system permease protein Aa4R_1401 ENOG4108WJH Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane (By similarity) Aa4R_1406 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) Aa4R_1415 ENOG4105KUZ arsenate reductase Aa4R_1416 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) Aa4R_1422 ENOG4105CPF Cell wall formation (By similarity) Aa4R_1437 ENOG4105GBT ABC transporter Aa4R_144 ENOG4105RT1 May be involved in cell division (By similarity) Aa4R_1463 ENOG4105C8J )-transporter Aa4R_1464 ENOG4108R99 pseudouridine synthase Aa4R_1476 ENOG4105WMJ Positive regulator of sigma E, RseC MucC Aa4R_1493 ENOG4105CNN ABC, transporter Aa4R_1494 ENOG4105CMG Carbohydrate kinase Aa4R_1506 ENOG410601J HemY protein Aa4R_151 ENOG4105CMS peptidase U62, modulator of DNA gyrase Aa4R_1510 ENOG4107T0K Adenylate cyclase Aa4R_1514 ENOG4105C9X ppx gppa phosphatase Aa4R_1524 ENOG4105ENX hydrolase Aa4R_1530 ENOG4105CPC Aldo Keto reductase Aa4R_1551 ENOG4107QKV phosphomannomutase Aa4R_156 ENOG4108R96 Methyltransferase, YaeB family Aa4R_1561 ENOG4105CJ2 (LipO)protein Aa4R_1578 ENOG4107QKW extracellular solute-binding protein family 1 Aa4R_158 ENOG4105DZR Type I site-specific deoxyribonuclease Aa4R_1581 ENOG4105FBT Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs (By similarity) Aa4R_1582 ENOG4105FBT Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs (By similarity) Aa4R_1586 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) Aa4R_159 ENOG4105DZR Type I site-specific deoxyribonuclease Aa4R_1595 ENOG41080IJ Diacylglycerol kinase Aa4R_1599 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) Aa4R_160 ENOG4105DZR Type I site-specific deoxyribonuclease Aa4R_161 ENOG4105CVR type I restriction-modification system Aa4R_1611 ENOG4108RR8 protoporphyrinogen oxidase Aa4R_1639 ENOG4105CWM branched-chain amino acid transport system II carrier protein Aa4R_1640 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase Aa4R_1643 ENOG4108X4Q Hydrolase Aa4R_1644 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) Aa4R_1646 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit Aa4R_1648 ENOG4105CXB phosphoribosylaminoimidazole synthetase Aa4R_1649 ENOG4108V3E phosphoribosylglycinamide formyltransferase Aa4R_1651 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) Aa4R_1679 ENOG4108Q79 6-phosphogluconolactonase (EC 3.1.1.31) Aa4R_168 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) Aa4R_1681 ENOG4108RNI 3'(2')5'-bisphosphate nucleotidase Aa4R_1682 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) Aa4R_1683 ENOG4108RNI 3'(2')5'-bisphosphate nucleotidase Aa4R_1687 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) Aa4R_1699 ENOG4105DC8 reductase Aa4R_1720 ENOG4105BZS acriflavin resistance protein Aa4R_1727 ENOG4105E0M Sulfatase Aa4R_1733 ENOG4105E07 UPF0149 protein Aa4R_1743 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) Aa4R_1746 ENOG4105CXY transporter Aa4R_1755 ENOG4105BZ1 (ABC) transporter Aa4R_1767 ENOG4105CV2 Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates (By similarity) Aa4R_1768 ENOG4106NZV Responsible for synthesis of pseudouridine from uracil- 13 in transfer RNAs (By similarity) Aa4R_1773 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) Aa4R_1777 ENOG4105C7B Threonine dehydratase Aa4R_1779 ENOG4105DQF Hydrolase Aa4R_178 ENOG4105N21 Membrane Aa4R_1781 ENOG4105PF3 O-Antigen polymerase Aa4R_1786 ENOG4105EIB trna rrna methyltransferase Aa4R_1799 ENOG4105C0R drug resistance transporter emrb qaca subfamily Aa4R_1801 ENOG4105DAS pts system Aa4R_1802 ENOG4105ETZ PTS System Aa4R_1803 ENOG4105F3R pts system mannose fructose sorbose family iid Aa4R_1806 ENOG4107RUE extracellular solute-binding protein family 1 Aa4R_1827 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter Aa4R_1834 ENOG4108V1T peptidylprolyl cis-trans isomerase Aa4R_1842 ENOG4105CJP fad dependent oxidoreductase Aa4R_1847 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate Aa4R_1851 ENOG4107FB0 transcriptional regulator DeoR family Aa4R_1860 ENOG4105XB7 anti-repressor protein Aa4R_187 ENOG4105GPY SprT protein Aa4R_1878 ENOG4105CV1 Transketolase (EC 2.2.1.1) Aa4R_1890 ENOG4105IYZ Electron transfer subunit of the periplasmic nitrate reductase complex NapAB (By similarity) Aa4R_1891 ENOG4105CUW cytochrome C-TYPE protein Aa4R_1892 ENOG4106032 Glutathionylspermidine synthase Aa4R_1893 ENOG4105XA0 heptosyltransferase ii Aa4R_19 ENOG4105DTZ bifunctional PTS system fructose-specific transporter subunit IIA HPr protein Aa4R_1926 ENOG4105D9N nucleoside Aa4R_1927 ENOG410667J hydrolase Aa4R_1937 ENOG4105CIC tryptophan-specific transport protein Aa4R_194 ENOG4105C05 Multifunctional regulator of fatty acid metabolism (By similarity) Aa4R_1941 ENOG4105C4N this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity) Aa4R_1942 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein Aa4R_1943 ENOG410903C (LipO)protein Aa4R_1948 ENOG4105PXI polysaccharide deacetylase Aa4R_1949 ENOG4105C0P Mg chelatase subunit ChlI Aa4R_196 ENOG410635M Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein (By similarity) Aa4R_1976 ENOG4105D01 (LipO)protein Aa4R_1980 ENOG4108RNI 3'(2')5'-bisphosphate nucleotidase Aa4R_1983 ENOG4108KBJ Inner membrane protein YkgB Aa4R_1985 ENOG4107RK2 ADP-ribose diphosphatase NudE Aa4R_1986 ENOG4107Y3D HAD-superfamily hydrolase subfamily IA variant 3 Aa4R_1987 ENOG4105VEJ Heat shock protein Aa4R_1990 ENOG4105X8U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity) Aa4R_1991 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) Aa4R_1997 ENOG41063VX Inherit from COG: glutaredoxin-related protein Aa4R_2 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) Aa4R_2000 ENOG4108NEM leader-binding protein dmsD Aa4R_2002 ENOG4105QAX Iron-sulfur Aa4R_2010 ENOG4106KVJ cytochrome C assembly protein Aa4R_2016 ENOG4105VUF Transcriptional regulator Aa4R_2017 ENOG4105EMU Dehydrogenase Aa4R_2026 ENOG41060A7 DNA polymerase beta domain protein region Aa4R_2050 ENOG4105DZP Membrane-associated zinc metalloprotease Aa4R_2051 ENOG4105KNE Phosphatidate cytidylyltransferase Aa4R_2059 ENOG41063SR receptor Aa4R_2063 ENOG4105M78 Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide (By similarity) Aa4R_2065 ENOG4105CGY Dna recombination protein Aa4R_2078 ENOG4105C1A potassium transporter peripheral membrane Aa4R_2080 ENOG4105KQT Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome (By similarity) Aa4R_209 ENOG4107EV4 once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system (By similarity) Aa4R_2095 ENOG4105DBV ornithine carbamoyltransferase Aa4R_2110 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) Aa4R_2118 ENOG4105DQ6 Transposase Aa4R_223 ENOG4105JJ8 Cytochrome c nitrite reductase, pentaheme subunit Aa4R_225 ENOG4105DVI reductase, NrfD Aa4R_23 ENOG4108Z33 Thiol disulfide Interchange Protein Aa4R_230 ENOG4105CBX hi0933 family Aa4R_240 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) Aa4R_242 ENOG4105NVJ RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) Aa4R_25 ENOG4107R9T Catalyzes the formation of 5-methyl-uridine at position 54 (m5U54) in all tRNAs (By similarity) Aa4R_251 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) Aa4R_252 ENOG4105D1Q UPF0246 protein Aa4R_262 ENOG4105C6N Formate acetyltransferase Aa4R_266 ENOG4107S7E 1-acyl-sn-glycerol-3-phosphate acyltransferase Aa4R_274 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein Aa4R_277 ENOG4105DH7 May be involved in recombination (By similarity) Aa4R_28 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) Aa4R_284 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) Aa4R_292 ENOG4108VPT UPF0234 protein Aa4R_293 ENOG4105CUR 5'-nucleotidase, lipoprotein e(p4) family Aa4R_296 ENOG4105CA3 membrane-bound lytic murein transglycosylase Aa4R_313 ENOG4108URH decarboxylase Aa4R_320 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component Aa4R_33 ENOG4105C6Z Gluconate Aa4R_340 ENOG4105CXY transporter Aa4R_346 ENOG4105K3M )-transporter Aa4R_371 ENOG4105D8J Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity) Aa4R_374 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) Aa4R_377 ENOG4105DDI hemolysin-type calcium-binding region Aa4R_378 ENOG4108JJA ABC, transporter Aa4R_382 ENOG4105E61 Mannitol repressor protein Aa4R_383 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) Aa4R_389 ENOG4105DH8 myo-inositol catabolism Aa4R_392 ENOG4105C26 Dehydrogenase Aa4R_417 ENOG4105CIH Imidazole acetol-phosphate transaminase Aa4R_420 ENOG41090HJ UPF0265 protein Aa4R_424 ENOG4105C5T Phosphoribosyl pyrophosphate synthase Aa4R_427 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate Aa4R_437 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter Aa4R_439 ENOG4107T42 This enzyme scavenge exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis (By similarity) Aa4R_441 ENOG4105D38 putrescine abc transporter Aa4R_443 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) Aa4R_445 ENOG4105DY2 Paraquat-inducible protein b Aa4R_446 ENOG4105H2K paraquat-inducible protein a Aa4R_45 ENOG4105C37 (CBS) domain Aa4R_451 ENOG4105C5X domain protein Aa4R_452 ENOG4105C5X domain protein Aa4R_457 ENOG4105CMV Succinyl-CoA synthetase subunit beta Aa4R_458 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha Aa4R_461 ENOG4105I6X formate hydrogenlyase maturation Aa4R_462 ENOG4105C47 NADH ubiquinone oxidoreductase 20 kda subunit Aa4R_473 ENOG4108MG3 formate dehydrogenase Aa4R_478 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) Aa4R_487 ENOG4108ZPC Polysaccharide pyruvyl transferase Aa4R_489 ENOG41068D6 Glycosyltransferase Aa4R_50 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) Aa4R_517 ENOG4105EYK Phosphatidylglycerophosphatase B Aa4R_534 ENOG4105CA0 peroxidase Aa4R_542 ENOG4107XHZ cytoplasmic chaperone TorD family protein Aa4R_55 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) Aa4R_550 ENOG4105C4Q deoxyguanosinetriphosphate triphosphohydrolase-like protein Aa4R_551 ENOG4105C5H ABC transporter Aa4R_560 ENOG4105EM2 membrane Aa4R_572 ENOG4105C0D helicase Aa4R_576 ENOG4105DSS Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) Aa4R_582 ENOG4108MJ5 VirK protein Aa4R_591 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) Aa4R_599 ENOG4105HPZ Involved in the removal of murein from the sacculus. May also facilitate integration of nascent murein strands into the sacculus by cleaving the peptide bonds between neighboring strands in mature murein (By similarity) Aa4R_611 ENOG4108K3A Glutathione S-transferase Aa4R_624 ENOG4105CG6 trap dicarboxylate transporter dctm subunit Aa4R_626 ENOG4105C9S Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P) (By similarity) Aa4R_628 ENOG4105QEK Transcriptional regulator Aa4R_64 ENOG4105CHR reductase Aa4R_640 ENOG4105CQ7 ATP-dependent helicase Aa4R_651 ENOG4107RBB ABC transporter, permease Aa4R_658 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) Aa4R_659 ENOG4105E1P Modifies, by uridylylation or deuridylylation the PII (GlnB) regulatory protein (By similarity) Aa4R_664 ENOG4108EU3 peptide transport system, permease Aa4R_674 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) Aa4R_678 ENOG410838F Glycosyl transferase family 2 Aa4R_68 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) Aa4R_687 ENOG4105DGW oligopeptidase A Aa4R_711 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) Aa4R_72 ENOG4105CJN penicillin-binding protein Aa4R_720 ENOG4107T9C Alpha amylase catalytic region Aa4R_722 ENOG4105D56 permease protein Aa4R_724 ENOG4108IJ9 (ABC) transporter Aa4R_729 ENOG4105CVM Molybdenum cofactor synthesis domain protein Aa4R_731 ENOG4106HRJ d-alanyl-d-alanine carboxypeptidase Aa4R_739 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) Aa4R_740 ENOG4107XNE ABC transporter, periplasmic molybdate-binding protein Aa4R_742 ENOG4108VEN abc transporter atp-binding protein Aa4R_747 ENOG4105HMI Membrane Aa4R_748 ENOG4108JQB penicillin-binding protein 1C Aa4R_754 ENOG41064BZ L-xylulose 5-phosphate 3-epimerase Aa4R_760 ENOG4108DBC nitroreductase Aa4R_776 ENOG4105CW7 secretion protein, HlyD family Aa4R_781 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) Aa4R_797 ENOG4105C45 hydrogenase expression formation protein (HypE) Aa4R_80 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) Aa4R_802 ENOG4105F9E Shikimate 5-dehydrogenase Aa4R_804 ENOG4108K5H permease YjgP YjgQ family protein Aa4R_807 ENOG4105CGB Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system (By similarity) Aa4R_810 ENOG4105F4R Transcriptional regulator mode Aa4R_814 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) Aa4R_830 ENOG4105C8J )-transporter Aa4R_863 ENOG4105DYN CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. May be involved in the integration of spacer DNA into the CRISPR cassette (By similarity) Aa4R_867 ENOG4106SMU thiamine transporter membrane protein Aa4R_886 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) Aa4R_898 ENOG4105PF0 Antitoxin component of a toxin-antitoxin (TA) module. Functions as an mRNA interferase antitoxin Aa4R_90 ENOG4108IQE Amp-dependent synthetase and ligase Aa4R_908 ENOG4105CEE C4-dicarboxylate transporter Aa4R_909 ENOG4105K7D Required for maturation of 30S ribosomal subunits (By similarity) Aa4R_912 ENOG4107QMH DNA methylase Aa4R_920 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) Aa4R_936 ENOG41085JB UPF0434 protein Aa4R_937 ENOG4105CHD Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) (By similarity) Aa4R_939 ENOG4108EQH DNA internalization-related competence protein ComEC Rec2 Aa4R_940 ENOG4105SVQ Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters. Also required for regulation of fis expression (By similarity) Aa4R_949 ENOG4107RTM 4-alpha-glucanotransferase (EC 2.4.1.25) Aa4R_955 ENOG4107QN2 dihydrolipoyl dehydrogenase Aa4R_956 ENOG41069NU Nitroreductase Aa4R_957 ENOG4105D07 Signal peptide peptidase, SppA Aa4R_959 ENOG4105EHE chorismate mutase- prephenate dehydrogenase Aa4R_960 ENOG4105EHE chorismate mutase- prephenate dehydrogenase Aa4R_963 ENOG4107R11 Transcriptional regulator Aa4R_976 ENOG41077A9 carbonic anhydrase Aa4R_985 ENOG4105ERU peptidase Aa4R_992 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) Aa4R_994 ENOG41082NX 50s ribosomal protein l35 Aa4S_1 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) Aa4S_1008 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) Aa4S_1020 ENOG4105CVS RNA methyltransferase TrmH family, group 1 Aa4S_103 ENOG4107QHF type ii secretion system protein e Aa4S_1038 ENOG4105E9S glutaredoxin 2 Aa4S_1039 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) Aa4S_1058 ENOG4105MZG transcriptional modulator of maze toxin, mazf Aa4S_1064 ENOG4108XTF Outer Membrane Lipoprotein Aa4S_1092 ENOG4107104 thymidine kinase Aa4S_1097 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) Aa4S_1099 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) Aa4S_1118 ENOG4105K8R UPF0145 protein Aa4S_1128 ENOG4105CFH Aspartokinase Aa4S_1132 ENOG4108IJ8 ABC transporter Aa4S_1135 ENOG4107EG0 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) Aa4S_114 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) Aa4S_1144 ENOG4105EE5 Membrane protein terC Aa4S_1150 ENOG4107R0E Glycosyl transferase, family 2 Aa4S_1179 ENOG4105CIY formyltetrahydrofolate deformylase Aa4S_1183 ENOG4107QVT Binding-protein-dependent transport systems, inner membrane component Aa4S_1184 ENOG4108IJ6 ABC transporter Aa4S_1185 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) Aa4S_1187 ENOG4106JDA Phosphoglycerate transport regulatory protein PGTC Aa4S_1190 ENOG4107TXD phosphoglycerate transport system transcriptional regulatory protein pgta Aa4S_1194 ENOG4105DR9 pseudouridine synthase Aa4S_1200 ENOG41090EX DsrE family Aa4S_1202 ENOG4107QYX exodeoxyribonuclease v alpha Aa4S_1210 ENOG4107QPK )-transporter Aa4S_1211 ENOG4105UNS Pfam:DUF419 Aa4S_1212 ENOG4107QY8 reductase Aa4S_125 ENOG4105DNI Converts SHCHC to OSB (By similarity) Aa4S_1250 ENOG41061GT Aldolase Aa4S_1252 ENOG4105CA9 Pyruvate kinase Aa4S_1257 ENOG4105EMU Dehydrogenase Aa4S_1259 ENOG4108MVK Receptor Aa4S_1260 ENOG4105D9Q decarboxylase (Beta subunit) Aa4S_1266 ENOG4105DK0 Indole-3-glycerol phosphate synthase Aa4S_1267 ENOG41082AG Plasmid maintenance system antidote protein Aa4S_1269 ENOG4107QYG anthranilate phosphoribosyltransferase Aa4S_1271 ENOG4105DDQ anthranilate synthase Aa4S_1277 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) Aa4S_1279 ENOG4108QBX (LipO)protein Aa4S_1286 ENOG4105E0A ABC, transporter Aa4S_1289 ENOG4105X1Q TOBE domain protein Aa4S_1290 ENOG4105S10 periplasmic binding protein Aa4S_1292 ENOG4105EHG Permease protein Aa4S_1295 ENOG4105CMI transporter Aa4S_1296 ENOG4105CJ1 ABC, transporter Aa4S_1301 ENOG4107QYT Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity) Aa4S_1302 ENOG4105DB7 PHP domain protein Aa4S_1303 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) Aa4S_1306 ENOG4105DS0 Transcriptional regulator, Crp Fnr family Aa4S_131 ENOG4105D4P Coproporphyrinogen iii oxidase Aa4S_1314 ENOG4105CJB Exodeoxyribonuclease I Aa4S_1322 ENOG4105KW6 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) Aa4S_1328 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) Aa4S_1330 ENOG4108ZZ3 UPF0260 protein Aa4S_1345 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) Aa4S_1375 ENOG4105E1C Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1A (PBP1a) (By similarity) Aa4S_1376 ENOG41082RQ UPF0102 protein Aa4S_1383 ENOG4107H6E Aa4S_1385 ENOG4107B7Y DNA-binding transcriptional regulator FruR Aa4S_1386 ENOG4107GZ4 SanA protein Aa4S_139 ENOG4105MRB Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose (By similarity) Aa4S_1390 ENOG4105XW2 UPF0263 protein Aa4S_1391 ENOG4105DMJ Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate (By similarity) Aa4S_1394 ENOG4107RTD sua5 ycio yrdc ywlc family protein Aa4S_14 ENOG4105DA4 cytochrome c-type biogenesis protein Aa4S_140 ENOG4105C2J ABC transporter Aa4S_1400 ENOG4107QSN dihydrolipoamide acetyltransferase Aa4S_1404 ENOG4107QQN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) Aa4S_1410 ENOG4108DNC Involved in acetate metabolism (By similarity) Aa4S_1413 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase Aa4S_1427 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) Aa4S_143 ENOG4108RVA ribokinase Aa4S_1432 ENOG4105C15 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) Aa4S_1441 ENOG4105C0D helicase Aa4S_1444 ENOG4107QHU One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) Aa4S_1445 ENOG4105CHV Transcription elongation factor NusA Aa4S_1452 ENOG4108KU3 Integrase Aa4S_146 ENOG4108ST3 glycosyltransferase Aa4S_1474 ENOG4105EYM Major Facilitator superfamily Aa4S_1478 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) Aa4S_148 ENOG4105D82 Glutamate dehydrogenase Aa4S_1483 ENOG4105DDY UPF0142 protein ycaO Aa4S_1487 ENOG4107T0D ABC, transporter Aa4S_149 ENOG4105CH6 catalase Aa4S_1493 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) Aa4S_1498 ENOG4105CE6 Adenylation and deadenylation of glutamate--ammonia ligase (By similarity) Aa4S_1501 ENOG4105C8A Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity) Aa4S_1503 ENOG4105CDH Citrulline--aspartate ligase Aa4S_1504 ENOG4106CC8 Bacterial inner membrane protein Aa4S_1506 ENOG4105DHQ Histidine kinase Aa4S_1509 ENOG4107H6E Aa4S_151 ENOG4105C0B DNA polymerase III (alpha subunit) Aa4S_1527 ENOG4105DZB Electron transport complex Aa4S_1530 ENOG4107QTR Required for nitrogen fixation. May be part of a membrane complex functioning as an intermediate in the electron transport to nitrogenase (By similarity) Aa4S_1532 ENOG4105DGN Electron transport complex Aa4S_1537 ENOG4105CM2 brancheD-chain amino acid aminotransferase Aa4S_1539 ENOG4105EZ6 Catalyzes the 2'-O-methylation at nucleotide C2498 in 23S rRNA (By similarity) Aa4S_1542 ENOG4105C0H protease Aa4S_1550 ENOG4108M8S permease YjgP YjgQ family protein Aa4S_1561 ENOG4108JJB ABC transporter Aa4S_1565 ENOG4105UZ0 ABC-type Co2 transport system, periplasmic component Aa4S_1566 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) Aa4S_1568 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) Aa4S_1575 ENOG4107QNR UPF0135 protein Aa4S_158 ENOG4108RDD Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine (By similarity) Aa4S_1582 ENOG4105CAF HipA N-terminal domain protein Aa4S_1591 ENOG4105C9Q fumarate hydratase class II Aa4S_1617 ENOG4108Z66 YbaK ebsC protein Aa4S_1618 ENOG4107QI1 Mate efflux family protein Aa4S_1623 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) Aa4S_1629 ENOG4107W52 maltose operon periplasmic protein Aa4S_1634 ENOG4105EG2 ABC transporter, permease Aa4S_1637 ENOG4107RCV ABC transporter, permease Aa4S_1651 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) Aa4S_1656 ENOG4105CDU Replicative dna helicase Aa4S_1659 ENOG4105D60 lipoprotein releasing system transmembrane protein Aa4S_1660 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) Aa4S_1670 ENOG4105C5Y PTS System Aa4S_1677 ENOG4105CCX Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) Aa4S_1680 ENOG4105K8N protein family UPF0079, ATPase Aa4S_1681 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase Aa4S_1695 ENOG4105ESV Glycosyl transferase, family 4 Aa4S_17 ENOG4105D3S 4Fe-4S Ferredoxin, iron-sulfur binding domain protein Aa4S_1702 ENOG4107SJW iron permease, FTR1 Aa4S_1719 ENOG4105M2J Glutaredoxin Aa4S_1721 ENOG4105CQB FAD linked oxidase domain protein Aa4S_1726 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) Aa4S_1733 ENOG4108MX5 Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses (By similarity) Aa4S_1734 ENOG4105CI1 PTS System Aa4S_1737 ENOG4105D7X high-affinity nickel-transporter Aa4S_175 ENOG4107RGD Major Facilitator superfamily Aa4S_1753 ENOG4107QMP dna polymerase iii subunits gamma and tau Aa4S_1758 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase Aa4S_1769 ENOG4105CFV Tetratricopeptide repeat protein Aa4S_1772 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) Aa4S_1773 ENOG4105CAT Cytidine monophosphate kinase Aa4S_1776 ENOG4107RAN Peptidase, M16 Aa4S_1777 ENOG4105KMT branched-chain amino acid Aa4S_1783 ENOG4105C0D helicase Aa4S_1799 ENOG4108IUS Transketolase Aa4S_1810 ENOG4105C9B Cysteine desulfurase Aa4S_1812 ENOG4105DW0 Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity) Aa4S_1817 ENOG4107QX8 SPFH domain, Band 7 family protein Aa4S_1823 ENOG4105ZIE Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides (By similarity) Aa4S_1824 ENOG4105CEY Amp-dependent synthetase and ligase Aa4S_1825 ENOG4105R8X Outer membrane lipoprotein Slp Aa4S_1826 ENOG41072GX Peptidase M22 Glycoprotease Aa4S_1829 ENOG4107QR8 Thioredoxin Aa4S_1832 ENOG4108JJ8 (ABC) transporter Aa4S_1837 ENOG4105F3T (LipO)protein Aa4S_1851 ENOG4106N3V dolichyl-phosphate beta-D-mannosyltransferase (EC 2.4.1.83) Aa4S_1871 ENOG4105KRQ Addiction module toxin, Txe YoeB family Aa4S_1872 ENOG41080C8 DUF218 domain Aa4S_1874 ENOG4105C4R Atp-dependent dna helicase Aa4S_1875 ENOG4105C6Z Gluconate Aa4S_1877 ENOG4105DIQ Transcriptional regulator Aa4S_1886 ENOG4108MFN small subunit of hydrogenase-3, iron-sulfur protein (part of formate hydrogenlyase (FHL) complex) Aa4S_1887 ENOG4108JPZ Monovalent cation H antiporter subunit D Aa4S_1888 ENOG4107TDF Formate hydrogenlyase subunit 4 Aa4S_1889 ENOG4105D65 subunit l Aa4S_1901 ENOG4105C7S Dehydrogenase Aa4S_1902 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 Aa4S_194 ENOG4105DWK Membrane Aa4S_1955 ENOG4107ENK receptor Aa4S_1959 ENOG4105C2J ABC transporter Aa4S_2 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) Aa4S_200 ENOG4107QRG dna polymerase iii Aa4S_201 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) Aa4S_2012 ENOG4108WWS isoprenylcysteine carboxyl methyltransferase Aa4S_2016 ENOG4107ENK receptor Aa4S_2030 ENOG4105QYV Membrane Aa4S_2031 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control Aa4S_2047 ENOG4105EI2 Pseudouridine synthase Aa4S_205 ENOG4105ZXK Dehydrogenase Aa4S_2057 ENOG4105CZI D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1 Aa4S_206 ENOG4105G63 Type III effector Hrp-dependent Aa4S_2067 ENOG4105CJR Integral membrane protein (MviN Aa4S_2075 ENOG4105D8G Major Facilitator superfamily Aa4S_2077 ENOG4105II7 pyrroline-5-carboxylate reductase Aa4S_2080 ENOG4108UBT opacity-associated protein Aa4S_2092 ENOG4105F1A Pyruvate formate-lyase Aa4S_2094 ENOG4105TMB Formate nitrite transporter Aa4S_2101 ENOG41076HS cation diffusion facilitator family transporter Aa4S_2107 ENOG4105C3F Signal peptidase i Aa4S_2110 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) Aa4S_216 ENOG4105FFN Specifically methylates the guanosine in position 1516 of 16S rRNA (By similarity) Aa4S_224 ENOG4105DE4 1-phosphofructokinase Aa4S_237 ENOG4108VZM 50s ribosomal protein L10 Aa4S_239 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) Aa4S_248 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity Aa4S_257 ENOG4105CRW Short chain fatty acid transporter Aa4S_264 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) Aa4S_267 ENOG4108I5U Uridine phosphorylase Aa4S_269 ENOG4105K89 arsenate reductase Aa4S_274 ENOG4105Z2P Protein of unknown function (DUF465) Aa4S_280 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B Aa4S_288 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) Aa4S_292 ENOG4105C0P Mg chelatase subunit ChlI Aa4S_299 ENOG4105CS6 Rhs element vgr protein Aa4S_315 ENOG41063SB peptidase Aa4S_327 ENOG4105ERG peptidase m48, ste24p Aa4S_33 ENOG4105C2C drug resistance transporter, Bcr CflA Aa4S_330 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) Aa4S_358 ENOG4105C4R Atp-dependent dna helicase Aa4S_36 ENOG4105C6K Malic enzyme Aa4S_361 ENOG4105C2M dna polymerase I Aa4S_367 ENOG4105CUI Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose (By similarity) Aa4S_374 ENOG4108BGM Quinol dehydrogenase periplasmic component Aa4S_39 ENOG4105CGZ zinc metallopeptidase Aa4S_392 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) Aa4S_398 ENOG4105EBW Rhomboid-type serine protease that catalyzes intramembrane proteolysis (By similarity) Aa4S_417 ENOG4107QWE )-transporter Aa4S_418 ENOG4108UMZ Cdp-alcohol phosphatidyltransferase Aa4S_421 ENOG4108HPI phosphatidate Cytidylyltransferase Aa4S_429 ENOG4105C5H ABC transporter Aa4S_432 ENOG410689M (LipO)protein Aa4S_433 ENOG4105DFP Integrase Aa4S_453 ENOG4105ED7 Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity) Aa4S_460 ENOG4105EAB amino acid AbC transporter Aa4S_461 ENOG4105E5Q amino acid AbC transporter Aa4S_465 ENOG4108ZAT Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE (By similarity) Aa4S_469 ENOG4105EHV domain protein Aa4S_472 ENOG4105BZ1 (ABC) transporter Aa4S_473 ENOG4108JJ9 ABC, transporter Aa4S_476 ENOG4105IX2 One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA (By similarity) Aa4S_483 ENOG4105ECR NmrA family Aa4S_492 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) Aa4S_502 ENOG4105C0R drug resistance transporter emrb qaca subfamily Aa4S_506 ENOG4108HWW ABC transporter Aa4S_507 ENOG4105C2J ABC transporter Aa4S_510 ENOG4105CMG Carbohydrate kinase Aa4S_515 ENOG4105JIM Phosphatidylserine synthase Aa4S_517 ENOG4105K5D 4fe-4S ferredoxin iroN-sulfur binding Aa4S_520 ENOG4105D2N Aldolase Aa4S_522 ENOG4108EUD Lysophospholipase Aa4S_530 ENOG4105DJV ribulose-phosphate 3-epimerase Aa4S_536 ENOG4108UM1 dedA family Aa4S_540 ENOG4106WTF Glycosyl transferase, family 2 Aa4S_555 ENOG4106MZZ glycerophosphoryl diester phosphodiesterase Aa4S_558 ENOG4105C2N RNA methyltransferase TrmH family group 3 Aa4S_568 ENOG4107RAQ aminopeptidase Aa4S_57 ENOG4105HDK L-asparaginase Aa4S_576 ENOG4105E0M Sulfatase Aa4S_577 ENOG4108RCM Nitroreductase Aa4S_583 ENOG410624X efflux transporter, rnd family, mfp subunit Aa4S_586 ENOG4105C25 Primosomal protein n' Aa4S_591 ENOG4105W1T Glycosyl Transferase Aa4S_598 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase Aa4S_604 ENOG4105D6S protein involved in catabolism of external DNA Aa4S_605 ENOG4108JQC penicillin-binding protein 1A Aa4S_610 ENOG4105E4G Type IV pilus Aa4S_612 ENOG4105D49 3-dehydroquinate synthase Aa4S_614 ENOG4108UUM single-stranded DNA-binding protein Aa4S_62 ENOG4105CUT histidyl-tRNA synthetase Aa4S_622 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving Aa4S_628 ENOG4105WV0 Glucose-6-phosphate 1-dehydrogenase (EC 1.1.1.49) Aa4S_630 ENOG41062MS nucleotidyltransferase substrate binding protein Aa4S_634 ENOG4108UK1 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity) Aa4S_637 ENOG4107QTF adenylosuccinate lyase Aa4S_640 ENOG4105VUF Transcriptional regulator Aa4S_652 ENOG4107QY8 reductase Aa4S_654 ENOG4107KGK dmso reductase anchor subunit Aa4S_66 ENOG4105C2W permease Aa4S_667 ENOG4105F4C Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity) Aa4S_67 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) Aa4S_671 ENOG4105E7U AraC family transcriptional regulator Aa4S_673 ENOG4105EPD Oligopeptide transporter, Opt family Aa4S_675 ENOG4108RNI 3'(2')5'-bisphosphate nucleotidase Aa4S_676 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase Aa4S_684 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) Aa4S_69 ENOG4105D9M gamma-glutamylcysteine synthetase Aa4S_698 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) Aa4S_71 ENOG4108I6E Sulfatase Aa4S_710 ENOG4105KQC Competence protein Aa4S_714 ENOG4107RUK Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins (By similarity) Aa4S_720 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) Aa4S_721 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits Aa4S_729 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) Aa4S_733 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) Aa4S_737 ENOG4108RS6 transposase Aa4S_743 ENOG4105D37 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity) Aa4S_747 ENOG4108UUE Transcriptional regulator Aa4S_753 ENOG4108IJ0 Aspartate ammonia-lyase Aa4S_76 ENOG4105NX3 Membrane Aa4S_761 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) Aa4S_767 ENOG4106XY2 Folate-binding protein involved in regulating the level of ATP-DnaA and in the modification of some tRNAs. It is probably a key factor in regulatory networks that act via tRNA modification, such as initiation of chromosomal replication (By similarity) Aa4S_77 ENOG4105C59 p-type ATPase Aa4S_775 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) Aa4S_783 ENOG4105IEY (LipO)protein Aa4S_806 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) Aa4S_810 ENOG4105E68 Sulfatase Aa4S_821 ENOG4105D7A ATP-binding protein Aa4S_834 ENOG4105K70 DNA-binding protein Aa4S_835 ENOG4105R2J Conserved Protein Aa4S_842 ENOG4105MA0 exported protein Aa4S_848 ENOG4105ECF c-methyltransferase Aa4S_852 ENOG4108WQI RNA Polymerase Aa4S_854 ENOG4108RRZ Transcription elongation factor GreB Aa4S_858 ENOG4107QPK )-transporter Aa4S_86 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase Aa4S_867 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) Aa4S_874 ENOG4105E7H involved in the assembly of LPS in the outer leaflet of the outer membrane. Determines N-hexane tolerance and is involved in outer membrane permeability. Essential for envelope biogenesis (By similarity) Aa4S_876 ENOG4105CIN aminoacyl-histidine dipeptidase Aa4S_88 ENOG4105C8P )-transporter Aa4S_889 ENOG4105KT7 mgtC SapB transporter Aa4S_909 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) Aa4S_913 ENOG4108JA2 transcriptioN-repair coupling factor Aa4S_915 ENOG4105E5Z arginine transporter ATP-binding subunit Aa4S_924 ENOG4105CJN penicillin-binding protein Aa4S_929 ENOG4105CNI cell division protein FtsW Aa4S_935 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) Aa4S_937 ENOG4105CQC Prephenate dehydratase Aa4S_942 ENOG41087AY ADP-Ribose pyrophosphatase Aa4S_95 ENOG4105DQ6 Transposase Aa4S_954 ENOG4105E33 succinate dehydrogenase Aa4S_957 ENOG4105CAP With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P (By similarity) Aa4S_963 ENOG4105KDX Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) Aa4S_965 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) Aa4S_983 ENOG4105CWG Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 (By similarity) Aa4S_986 ENOG4108HWV )-transporter Aa4S_988 ENOG4105C2J ABC transporter Aa4S_992 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) Aa5R_1 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) Aa5R_10 ENOG4105C6K Malic enzyme Aa5R_1000 ENOG4105C2J ABC transporter Aa5R_1023 ENOG4105D1F ATP-binding protein Aa5R_1024 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) Aa5R_1026 ENOG4108ZIT Ferredoxin, 2FE-2S Aa5R_1027 ENOG4105C9I Chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB Aa5R_1030 ENOG4107XTC May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins Aa5R_1034 ENOG4105ECY inositol monophosphatase Aa5R_1044 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) Aa5R_105 ENOG4108VBV N-Acetylmuramoyl-L-alanine amidase Aa5R_107 ENOG4107QHF type ii secretion system protein e Aa5R_1125 ENOG4105CDU Replicative dna helicase Aa5R_1162 ENOG4108EVY peptide transport periplasmic protein Aa5R_1164 ENOG4106K28 UPF0283 membrane protein Aa5R_1165 ENOG4108JU8 Transcriptional regulator Aa5R_117 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) Aa5R_1170 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) Aa5R_1171 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase Aa5R_1175 ENOG4105CCX Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) Aa5R_118 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) Aa5R_1180 ENOG4105KZ7 phosphocarrier protein hpr Aa5R_1181 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) Aa5R_1191 ENOG4105D60 lipoprotein releasing system transmembrane protein Aa5R_1194 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) Aa5R_1199 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) Aa5R_1201 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) Aa5R_1203 ENOG4105CCF Lysine exporter protein (Lyse ygga) Aa5R_121 ENOG4108IA2 Sodium pantothenate symporter Aa5R_1218 ENOG4107FKK extracellular solute-binding protein family 1 Aa5R_1230 ENOG4108R6K riboflavin synthase, subunit alpha Aa5R_1239 ENOG4105DN3 alpha-2-macroglobulin domain protein Aa5R_1282 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) Aa5R_1300 ENOG4105CGB Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system (By similarity) Aa5R_1311 ENOG4105CM2 brancheD-chain amino acid aminotransferase Aa5R_1315 ENOG4105ECP epimerase Aa5R_1317 ENOG4108R3D Electron transport complex Aa5R_1329 ENOG4105DHS permease protein Aa5R_1334 ENOG4105H4F exported protein Aa5R_1335 ENOG4105XJC Two component transcriptional regulator (Winged helix family Aa5R_1343 ENOG4107SRH Nad-dependent epimerase dehydratase Aa5R_135 ENOG4108HYK gCN5-related N-acetyltransferase Aa5R_1356 ENOG4105DYN CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. May be involved in the integration of spacer DNA into the CRISPR cassette (By similarity) Aa5R_1377 ENOG4105KAF membrAne Aa5R_1378 ENOG4105C7N Xanthine uracil vitamin C permease Aa5R_1381 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) Aa5R_1396 ENOG4105PF0 Antitoxin component of a toxin-antitoxin (TA) module. Functions as an mRNA interferase antitoxin Aa5R_1407 ENOG4105CHV Transcription elongation factor NusA Aa5R_1410 ENOG4105C0D helicase Aa5R_1417 ENOG4108IIE The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) Aa5R_1431 ENOG4105CHD Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) (By similarity) Aa5R_1433 ENOG4108EQH DNA internalization-related competence protein ComEC Rec2 Aa5R_145 ENOG4105C2J ABC transporter Aa5R_1454 ENOG4105EHE chorismate mutase- prephenate dehydrogenase Aa5R_1456 ENOG4107RTD sua5 ycio yrdc ywlc family protein Aa5R_1469 ENOG4107QIV Cytochrome c biogenesis protein Aa5R_147 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator Aa5R_1484 ENOG4105C22 threonyL-tRNA synthetase Aa5R_1499 ENOG4107WTH Galactitol-1-phosphate dehydrogenase Aa5R_1500 ENOG4105E98 transcriptional regulator DeoR family Aa5R_1509 ENOG4108W1A pseudouridine synthase Aa5R_1511 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA Aa5R_1528 ENOG4105CXW Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) Aa5R_1530 ENOG4108VD1 dedA family Aa5R_1554 ENOG4105CD8 aminopeptidase N Aa5R_1555 ENOG4105CGF Aromatic amino acid aminotransferase Aa5R_1586 ENOG4108V5Q transglutaminase-like protein Aa5R_1604 ENOG4106YXT transposase Aa5R_1609 ENOG4108MVK Receptor Aa5R_1619 ENOG41061GT Aldolase Aa5R_1626 ENOG4105DKT Transcriptional regulator Aa5R_1627 ENOG4107RYS Autoinducer-2 (AI-2) kinase Aa5R_1637 ENOG4105CHW UPF0052 protein Aa5R_164 ENOG4105EYA deoxyribonuclease Aa5R_1645 ENOG4107QPK )-transporter Aa5R_1654 ENOG4107QKA exodeoxyribonuclease V beta Aa5R_1656 ENOG4108RKI Necessary for the introduction of cis unsaturation into fatty acids. Catalyzes the dehydration of (3R)-3-hydroxydecanoyl- ACP to E-(2)-decenoyl-ACP and then its isomerization to Z-(3)- decenoyl-ACP. Can catalyze the dehydratase reaction for beta- hydroxyacyl-ACPs with saturated chain lengths up to 16 0, being most active on intermediate chain length (By similarity) Aa5R_1657 ENOG4105DAN ATP-dependent protease Aa5R_1665 ENOG4107TXD phosphoglycerate transport system transcriptional regulatory protein pgta Aa5R_1668 ENOG4106JDA Phosphoglycerate transport regulatory protein PGTC Aa5R_1671 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) Aa5R_1677 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) Aa5R_1682 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) Aa5R_1692 ENOG4105WI0 lipopolysaccharide transport periplasmic protein lptA Aa5R_1694 ENOG4105DHJ ABC, transporter Aa5R_1700 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) Aa5R_1707 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) Aa5R_1714 ENOG4105CI3 gtp-binding protein typa Aa5R_1744 ENOG4107SS6 2-dehydro-3-deoxygluconokinase Aa5R_1753 ENOG4105CHH sulfate transporter Aa5R_1767 ENOG4108RG0 uracil-dna glycosylase Aa5R_1769 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) Aa5R_1784 ENOG4108IFH alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen Aa5R_1787 ENOG4105MN5 HAD-superfamily hydrolase subfamily IA variant 3 Aa5R_179 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) Aa5R_1796 ENOG4105CQB FAD linked oxidase domain protein Aa5R_18 ENOG4105JJ8 Cytochrome c nitrite reductase, pentaheme subunit Aa5R_180 ENOG4107RGD Major Facilitator superfamily Aa5R_1805 ENOG4105C9S Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P) (By similarity) Aa5R_1806 ENOG4108ERU trap dicarboxylate transporter subunit DctP Aa5R_1833 ENOG4105HPZ Involved in the removal of murein from the sacculus. May also facilitate integration of nascent murein strands into the sacculus by cleaving the peptide bonds between neighboring strands in mature murein (By similarity) Aa5R_1835 ENOG4105EGS Mechanosensitive ion channel Aa5R_1852 ENOG4107RAN Peptidase, M16 Aa5R_1862 ENOG4108Z0T Part of a sulfur-relay system (By similarity) Aa5R_1866 ENOG4105CC5 ABC transporter Aa5R_187 ENOG4105C6B Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity) Aa5R_1873 ENOG4105C76 Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue (By similarity) Aa5R_1881 ENOG4105C4Q deoxyguanosinetriphosphate triphosphohydrolase-like protein Aa5R_1887 ENOG4105DW0 Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity) Aa5R_1888 ENOG4105D1S lipid A biosynthesis Aa5R_1897 ENOG4105CA0 peroxidase Aa5R_1902 ENOG4105DVT helicase Aa5R_1903 ENOG4105DSB aldose 1-epimerase Aa5R_1905 ENOG4105C3M thioredoxin reductase Aa5R_1907 ENOG4108JJ8 (ABC) transporter Aa5R_1923 ENOG4108KBE Glycosyl transferase, family 2 Aa5R_1927 ENOG4105WH5 Teichoic acid glycosylation protein Aa5R_1934 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase Aa5R_1936 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) Aa5R_1938 ENOG4105CVE Lytic murein transglycosylase Aa5R_1940 ENOG4108RJ9 Glycosyl transferase, family 2 Aa5R_1968 ENOG4105C8H hydrogenase maturation protein Hypf Aa5R_1974 ENOG4108JPZ Monovalent cation H antiporter subunit D Aa5R_2002 ENOG4105D1H recombination factor protein RarA Aa5R_201 ENOG4107XM3 UPF0442 protein Aa5R_2012 ENOG4108AD6 Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein (By similarity) Aa5R_2013 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) Aa5R_2014 ENOG4105C5T Phosphoribosyl pyrophosphate synthase Aa5R_2017 ENOG4105DAA L-lactate Aa5R_2021 ENOG4105CIH Imidazole acetol-phosphate transaminase Aa5R_2026 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase Aa5R_2039 ENOG4107QN8 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) Aa5R_2044 ENOG4105CNN ABC, transporter Aa5R_2046 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator Aa5R_2057 ENOG4105CJK Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity) Aa5R_206 ENOG4107QRG dna polymerase iii Aa5R_2067 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) Aa5R_2071 ENOG4108WPU DNA polymerase III subunit psi Aa5R_2072 ENOG4105KEG ribosomal-protein-alanine acetyltransferase Aa5R_2073 ENOG4105DSY exodeoxyribonuclease V, gamma Aa5R_2114 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control Aa5R_2118 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component Aa5R_2125 ENOG4108URH decarboxylase Aa5R_2127 ENOG4105MGM doxx family Aa5R_2128 ENOG4105C03 ribonuclease Aa5R_2146 ENOG4105NXV High-affinity zinc uptake system protein Aa5R_2148 ENOG4108VPT UPF0234 protein Aa5R_215 ENOG4105C6Z Gluconate Aa5R_2161 ENOG4105II7 pyrroline-5-carboxylate reductase Aa5R_2165 ENOG4108UBT opacity-associated protein Aa5R_2173 ENOG4105F10 Catalyzes the hydrolysis of the pyrophosphate bond of UDP-2,3-diacylglucosamine to yield 2,3-diacylglucosamine 1- phosphate (lipid X) and UMP (By similarity) Aa5R_2188 ENOG4105D1Q UPF0246 protein Aa5R_223 ENOG4108Z33 Thiol disulfide Interchange Protein Aa5R_229 ENOG4105DM4 PTS System Aa5R_243 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) Aa5R_257 ENOG4107QP7 CoA-transferase subunit A Aa5R_267 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) Aa5R_28 ENOG41060IM Heme exporter protein Aa5R_304 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) Aa5R_314 ENOG4105CWM branched-chain amino acid transport system II carrier protein Aa5R_320 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) Aa5R_352 ENOG41063VX Inherit from COG: glutaredoxin-related protein Aa5R_363 ENOG4107Y3D HAD-superfamily hydrolase subfamily IA variant 3 Aa5R_365 ENOG4105F4C Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity) Aa5R_378 ENOG4107KGK dmso reductase anchor subunit Aa5R_379 ENOG4105QAX Iron-sulfur Aa5R_394 ENOG4106KVJ cytochrome C assembly protein Aa5R_419 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving Aa5R_427 ENOG4108UUM single-stranded DNA-binding protein Aa5R_431 ENOG4105E4G Type IV pilus Aa5R_438 ENOG4105DC8 reductase Aa5R_439 ENOG4107RYR Transcriptional regulator, Crp Fnr family Aa5R_455 ENOG4105C25 Primosomal protein n' Aa5R_486 ENOG4106MZZ glycerophosphoryl diester phosphodiesterase Aa5R_492 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) Aa5R_493 ENOG4105E55 glycerol-3-phosphate acyltransferase Aa5R_494 ENOG4105BZ1 (ABC) transporter Aa5R_521 ENOG4105D2N Aldolase Aa5R_58 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) Aa5R_591 ENOG4105ED7 Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity) Aa5R_592 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) Aa5R_601 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) Aa5R_610 ENOG4107QWE )-transporter Aa5R_615 ENOG4105D7M Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) Aa5R_639 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase Aa5R_656 ENOG4105CUW cytochrome C-TYPE protein Aa5R_673 ENOG4105W39 Membrane Aa5R_693 ENOG410667J hydrolase Aa5R_696 ENOG4105DAS pts system Aa5R_713 ENOG4107QSU Phosphoglucomutase phosphomannomutase alpha beta alpha domain Aa5R_739 ENOG4108MJ5 VirK protein Aa5R_764 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) Aa5R_773 ENOG41066UG Regulatory DnaK co-chaperone. Direct interaction between DnaK and DjlA is needed for the induction of the wcaABCDE operon, involved in the synthesis of a colanic acid polysaccharide capsule, possibly through activation of the RcsB RcsC phosphotransfer signaling pathway. The colanic acid capsule may help the bacterium survive conditions outside the host (By similarity) Aa5R_779 ENOG41090ED Protein with unknown function (DUF469) Aa5R_784 ENOG4105IEY (LipO)protein Aa5R_795 ENOG4105CJ2 (LipO)protein Aa5R_809 ENOG4105DXN mazG family Aa5R_812 ENOG4105YDX UPF0352 protein Aa5R_830 ENOG4105CMA conjugation trbi family protein Aa5R_848 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) Aa5R_85 ENOG4108Z6Z Transcriptional regulator Aa5R_860 ENOG4105ECF c-methyltransferase Aa5R_862 ENOG4105EX9 Membrane Aa5R_863 ENOG4105EX9 Membrane Aa5R_877 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator Aa5R_879 ENOG4105CS9 pantothenic acid kinase Aa5R_932 ENOG4105DMR ABC, transporter Aa5R_944 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) Aa5R_957 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) Aa5R_973 ENOG4108IHU transport system permease protein Aa5R_976 ENOG4105DIN metallophosphoesterase Aa5S_1021 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) Aa5S_1028 ENOG4108SWN Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA (By similarity) Aa5S_1032 ENOG4108ZF1 Transcriptional regulator, BadM Rrf2 family Aa5S_1038 ENOG4105C4Y ABC transporter Aa5S_1051 ENOG4105E9S glutaredoxin 2 Aa5S_11 ENOG4105CBX hi0933 family Aa5S_111 ENOG41067SF Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase (By similarity) Aa5S_113 ENOG4105BZG amino acid carrier protein Aa5S_1137 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) Aa5S_1150 ENOG4105DQ6 Transposase Aa5S_1172 ENOG4105K8N protein family UPF0079, ATPase Aa5S_1185 ENOG4107TSG Extracellular solute-binding protein, family 5 Aa5S_1215 ENOG4107T9C Alpha amylase catalytic region Aa5S_1220 ENOG4108KDD Involved in the transport of maltose and maltodextrins (By similarity) Aa5S_1221 ENOG4107W52 maltose operon periplasmic protein Aa5S_1223 ENOG4105CVM Molybdenum cofactor synthesis domain protein Aa5S_1241 ENOG4108JQB penicillin-binding protein 1C Aa5S_1272 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH Aa5S_128 ENOG4105KM4 Acetyl-CoA carboxylase, biotin carboxyl carrier protein Aa5S_1283 ENOG4105UZ0 ABC-type Co2 transport system, periplasmic component Aa5S_129 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) Aa5S_1297 ENOG4108K5H permease YjgP YjgQ family protein Aa5S_1301 ENOG4105E0C molybdate abc transporter Aa5S_1303 ENOG4105F4R Transcriptional regulator mode Aa5S_1318 ENOG4107QTR Required for nitrogen fixation. May be part of a membrane complex functioning as an intermediate in the electron transport to nitrogenase (By similarity) Aa5S_1322 ENOG4105CSM endonuclease III Aa5S_1331 ENOG4107RNS bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase 3'-nucleotidase periplasmic Aa5S_1342 ENOG4105CDH Citrulline--aspartate ligase Aa5S_1360 ENOG4106SMU thiamine transporter membrane protein Aa5S_1363 ENOG4105C0H protease Aa5S_1390 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) Aa5S_1408 ENOG4107QHU One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) Aa5S_1409 ENOG4107QMH DNA methylase Aa5S_1439 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) Aa5S_1442 ENOG4107RTM 4-alpha-glucanotransferase (EC 2.4.1.25) Aa5S_1461 ENOG4105ETE Transcriptional regulator (LacI family Aa5S_1475 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) Aa5S_149 ENOG4105VEQ Cold shock protein Aa5S_1503 ENOG4107QTG Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity) Aa5S_1507 ENOG4105DWU Membrane Aa5S_151 ENOG4108ST3 glycosyltransferase Aa5S_152 ENOG4105CH7 arginosuccinase Aa5S_1520 ENOG4105DJY efflux transporter, rnd family, mfp subunit Aa5S_1528 ENOG4107QQN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) Aa5S_153 ENOG4105D82 Glutamate dehydrogenase Aa5S_1539 ENOG4105CJB Exodeoxyribonuclease I Aa5S_1541 ENOG4105DQ6 Transposase Aa5S_1545 ENOG41090A1 ferritin Aa5S_1558 ENOG4105CMI transporter Aa5S_1581 ENOG4105C2X Arabinose 5-phosphate isomerase Aa5S_1588 ENOG41082AG Plasmid maintenance system antidote protein Aa5S_1593 ENOG4106AFN Lyase and sodium transporter (By similarity) Aa5S_1594 ENOG4107QSA Oxaloacetate decarboxylase Aa5S_1604 ENOG4105R8V Transcriptional regulator Aa5S_1626 ENOG4105EWW Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) Aa5S_1627 ENOG4105DAG ROK family Aa5S_1629 ENOG4105KB2 stringent starvation protein b Aa5S_1646 ENOG4105K4U addiction module toxin, RelE StbE family Aa5S_1667 ENOG4108IJ6 ABC transporter Aa5S_1672 ENOG4108SAU DNA-binding protein H-ns Aa5S_1679 ENOG4105VFG Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity) Aa5S_1681 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase Aa5S_1689 ENOG4108IUZ ABC transporter Aa5S_1720 ENOG4105DFA alanine racemase domain protein Aa5S_1753 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) Aa5S_1762 ENOG4105EXN Sulfate transport protein CysZ Aa5S_1768 ENOG4105DQ6 Transposase Aa5S_1771 ENOG4105E1P Modifies, by uridylylation or deuridylylation the PII (GlnB) regulatory protein (By similarity) Aa5S_178 ENOG4105C1J atp-dependent rna helicase Aa5S_1806 ENOG4108MX5 Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses (By similarity) Aa5S_181 ENOG4107RGD Major Facilitator superfamily Aa5S_1810 ENOG4105D7X high-affinity nickel-transporter Aa5S_1813 ENOG4105C5H ABC transporter Aa5S_1815 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) Aa5S_1834 ENOG4107CDU Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated (By similarity) Aa5S_1840 ENOG4108ZJT translation initiation factor, Sui1 Aa5S_1847 ENOG4108MJ5 VirK protein Aa5S_1848 ENOG4105PE1 Receptor Aa5S_1854 ENOG4105DFS Conserved Protein Aa5S_1861 ENOG4105DIK (ABC) transporter Aa5S_1864 ENOG4105VSY K01512 acylphosphatase EC 3.6.1.7 Aa5S_1868 ENOG4105EM2 membrane Aa5S_1869 ENOG4108DG9 Smr protein MutS2 Aa5S_1881 ENOG4105KK6 nuclease Aa5S_1889 ENOG4107QX8 SPFH domain, Band 7 family protein Aa5S_1903 ENOG4108JJ9 ABC, transporter Aa5S_1909 ENOG4105F3T (LipO)protein Aa5S_1910 ENOG4105EZX Catalyzes the phosphorylation of N-acetyl-D-glucosamine (GlcNAc) derived from cell-wall degradation, yielding GlcNAc-6-P (By similarity) Aa5S_192 ENOG4105HSA Protein of unknown function (DUF452) Aa5S_1946 ENOG4105C4R Atp-dependent dna helicase Aa5S_1948 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family Aa5S_198 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) Aa5S_1993 ENOG4105F38 ABC transporter, permease Aa5S_1998 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter Aa5S_202 ENOG4108YYV Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) Aa5S_204 ENOG4105RX8 Protein of unknown function (DUF1523) Aa5S_2053 ENOG4108HRG Involved in the cleavage of the C1-C2 bond of 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (THcHDO) to yield 5-deoxy- glucuronate (5DG) (By similarity) Aa5S_2060 ENOG4108JJA ABC, transporter Aa5S_2072 ENOG4105KCK Peptidoglycan-associated lipoprotein Aa5S_2087 ENOG4105CDY transcriptional regulatory protein Aa5S_2098 ENOG4105DH5 Responsible for the end-turnover of tRNA specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A). Also appears to be involved in tRNA biosynthesis (By similarity) Aa5S_2101 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) Aa5S_2109 ENOG4105QYV Membrane Aa5S_2116 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component Aa5S_2136 ENOG4105EN6 Membrane Aa5S_214 ENOG4105QG4 Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity) Aa5S_2147 ENOG41062Z9 Membrane Aa5S_2163 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein Aa5S_217 ENOG4108K4B hydrolase Aa5S_2171 ENOG4107S7E 1-acyl-sn-glycerol-3-phosphate acyltransferase Aa5S_2179 ENOG4107QPA Cleaves GlcNAc linked beta-1,4 to MurNAc tripeptides (By similarity) Aa5S_2193 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins Aa5S_228 ENOG4105DE4 1-phosphofructokinase Aa5S_246 ENOG41083MP 50s ribosomal protein l29 Aa5S_25 ENOG4105DA4 cytochrome c-type biogenesis protein Aa5S_254 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) Aa5S_263 ENOG4105CSX c4-dicarboxylate anaerobic carrier Aa5S_283 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B Aa5S_286 ENOG4108RR8 protoporphyrinogen oxidase Aa5S_289 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein Aa5S_295 ENOG4108ZT0 50S ribosomal protein l17 Aa5S_301 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) Aa5S_313 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) Aa5S_321 ENOG4105KQC Competence protein Aa5S_361 ENOG4105E7U AraC family transcriptional regulator Aa5S_377 ENOG4108NEM leader-binding protein dmsD Aa5S_390 ENOG41067XB TonB family Aa5S_402 ENOG4107QTF adenylosuccinate lyase Aa5S_423 ENOG4105DQ6 Transposase Aa5S_461 ENOG4107QUT magnesium and cobalt transport protein CorA Aa5S_466 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase Aa5S_469 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase Aa5S_487 ENOG4105C79 DNA protecting protein DprA Aa5S_500 ENOG4105D8A 3-Deoxy-D-manno-octulosonic-acid transferase Aa5S_505 ENOG4108UM1 dedA family Aa5S_510 ENOG4105XX3 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) Aa5S_52 ENOG4105DKR Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) Aa5S_532 ENOG4105C93 Xylose Isomerase Aa5S_535 ENOG4108HWW ABC transporter Aa5S_541 ENOG4105DAS pts system Aa5S_567 ENOG4105D7W serine acetyltransferase Aa5S_570 ENOG4107YZP Rhodanese domain protein Aa5S_577 ENOG4105VRX Protein slyX homolog Aa5S_602 ENOG4105Y3E Modulates RecA activity (By similarity) Aa5S_612 ENOG4105D0V Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) Aa5S_617 ENOG4105E1Z Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane Aa5S_618 ENOG4105DZP Membrane-associated zinc metalloprotease Aa5S_63 ENOG4105HDK L-asparaginase Aa5S_631 ENOG4105M78 Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide (By similarity) Aa5S_633 ENOG4105CGY Dna recombination protein Aa5S_635 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) Aa5S_658 ENOG4105XA0 heptosyltransferase ii Aa5S_660 ENOG4105CUI Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose (By similarity) Aa5S_678 ENOG4105C1J atp-dependent rna helicase Aa5S_698 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) Aa5S_709 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein Aa5S_729 ENOG4105CS6 Rhs element vgr protein Aa5S_732 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) Aa5S_736 ENOG4105C0P Mg chelatase subunit ChlI Aa5S_737 ENOG4105WHM Necessary for normal cell division and for the maintenance of normal septation (By similarity) Aa5S_74 ENOG4105EIN peptidylprolyl cis-trans isomerase Aa5S_754 ENOG4105M5K heptosyltransferase Aa5S_772 ENOG4107QP2 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) Aa5S_775 ENOG4105FBT Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs (By similarity) Aa5S_785 ENOG4105M85 Bola protein Aa5S_802 ENOG4105QF0 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) Aa5S_805 ENOG4107QKV phosphomannomutase Aa5S_814 ENOG4105YRI Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) Aa5S_817 ENOG4105D6U Sodium Glutamate Symporter Aa5S_83 ENOG4105C59 p-type ATPase Aa5S_853 ENOG4105C9X ppx gppa phosphatase Aa5S_870 ENOG4107QPK )-transporter Aa5S_873 ENOG4105CMG Carbohydrate kinase Aa5S_889 ENOG4105CIN aminoacyl-histidine dipeptidase Aa5S_897 ENOG4105KPY Small multidrug resistance protein Aa5S_904 ENOG4108R99 pseudouridine synthase Aa5S_951 ENOG4105CQC Prephenate dehydratase Aa5S_974 ENOG4105DQ5 transport system permease protein Aa5S_996 ENOG4105CWG Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 (By similarity) Aggac_10 ENOG4108IYH Dna topoisomerase Aggac_1015 ENOG4105SYT Methylenetetrahydrofolate reductase Aggac_1022 ENOG4105CQS hydrogenase expression formation protein HypD Aggac_1026 ENOG4107XQ1 cobalamin (vitamin B12) biosynthesis CbiM protein Aggac_1029 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) Aggac_1032 ENOG4105T95 Thiol disulfide interChange protein Aggac_1036 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase Aggac_1037 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) Aggac_1042 ENOG4105CW7 secretion protein, HlyD family Aggac_1043 ENOG4105C0R drug resistance transporter emrb qaca subfamily Aggac_1053 ENOG4105MYG DNA polymerase iii, chi subunit Aggac_1058 ENOG4108DBC nitroreductase Aggac_1064 ENOG41064BZ L-xylulose 5-phosphate 3-epimerase Aggac_107 ENOG4108K6F triphosphoribosyl-dephospho-CoA synthase Aggac_1073 ENOG4105D1U peptidase U62 modulator of DNA gyrase Aggac_1074 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase Aggac_1077 ENOG4107XNE ABC transporter, periplasmic molybdate-binding protein Aggac_1092 ENOG4108KDD Involved in the transport of maltose and maltodextrins (By similarity) Aggac_1094 ENOG4107FKK extracellular solute-binding protein family 1 Aggac_1103 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) Aggac_1123 ENOG4105C5I Dehydrogenase Aggac_113 ENOG4105F0Z galactose-1-phosphate uridylyltransferase Aggac_1142 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) Aggac_1149 ENOG4105CM6 amino acid regulated cytosolic protein Aggac_1158 ENOG4105CH6 catalase Aggac_1167 ENOG4108RDD Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine (By similarity) Aggac_1178 ENOG4105CNI cell division protein FtsW Aggac_1179 ENOG4105CJN penicillin-binding protein Aggac_119 ENOG4105BZU Histidine kinase Aggac_1193 ENOG4105E78 Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) Aggac_1196 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) Aggac_1203 ENOG4105DWK Membrane Aggac_1208 ENOG4105F8V Hydrolase, tatD family Aggac_121 ENOG4105CWG Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 (By similarity) Aggac_1212 ENOG4108YZA Nitrogen regulatory protein pii Aggac_1213 ENOG4105MVE transcriptional regulator Aggac_1215 ENOG4105G63 Type III effector Hrp-dependent Aggac_1218 ENOG4105C6Z Gluconate Aggac_1221 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) Aggac_1244 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) Aggac_126 ENOG4105EIF outer membrane protein W Aggac_1260 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) Aggac_1282 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) Aggac_1298 ENOG4107EG0 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) Aggac_1299 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) Aggac_130 ENOG4105NAU thioesterase Superfamily protein Aggac_1321 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) Aggac_1323 ENOG4106J39 exported protein Aggac_1345 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) Aggac_1353 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) Aggac_1354 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) Aggac_1358 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) Aggac_1359 ENOG41067V7 50S ribosomal protein L36 Aggac_1366 ENOG4105VEI Removes the pyruvyl group from chorismate, with concomitant aromatization of the ring, to provide 4- hydroxybenzoate (4HB) for the ubiquinone pathway (By similarity) Aggac_1367 ENOG4105CB5 ATP-dependent DNA helicase recG Aggac_1372 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase Aggac_1374 ENOG4108Z1B Cyclase dehydrase Aggac_1398 ENOG4105EE5 Membrane protein terC Aggac_140 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) Aggac_1405 ENOG4105DQ6 Transposase Aggac_1408 ENOG4108VVQ metallophosphoesterase Aggac_1417 ENOG4105CBX hi0933 family Aggac_1418 ENOG4108DMF Cytochrome C biogenesis protein Aggac_1420 ENOG4105DA4 cytochrome c-type biogenesis protein Aggac_1429 ENOG4108M1T Cytochrome c-type biogenesis protein Aggac_1430 ENOG4107QX9 Thiol disulfide interChange protein Aggac_1437 ENOG4105C2C drug resistance transporter, Bcr CflA Aggac_1472 ENOG4105HSZ Cytoskeletal protein that is involved in cell-shape control through regulation of the length of the long axis (By similarity) Aggac_1483 ENOG4108I6E Sulfatase Aggac_1492 ENOG4105CVR type I restriction-modification system Aggac_1493 ENOG4105DZR Type I site-specific deoxyribonuclease Aggac_1499 ENOG4105N42 UPF0307 protein Aggac_1502 ENOG4105BZW Glycerate kinase Aggac_1503 ENOG4107QQ0 gntp family Aggac_1506 ENOG4105C1J atp-dependent rna helicase Aggac_151 ENOG4108WJH Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane (By similarity) Aggac_1519 ENOG4108WPH sigma 54 modulation protein ribosomal protein S30EA Aggac_1521 ENOG4105VY0 Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters (By similarity) Aggac_1527 ENOG4105RG0 Membrane Aggac_153 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) Aggac_1542 ENOG4105XCT Protein of unknown function (DUF2489) Aggac_1549 ENOG4105MRB Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose (By similarity) Aggac_1550 ENOG4105C2J ABC transporter Aggac_1568 ENOG4105FBT Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs (By similarity) Aggac_1569 ENOG4105FBT Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs (By similarity) Aggac_1574 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) Aggac_1575 ENOG4105CEN a g-specific adenine glycosylase Aggac_1585 ENOG4105F5D NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) Aggac_1593 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) Aggac_1597 ENOG4105GGQ This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis (By similarity) Aggac_1609 ENOG4105E3W Two component transcriptional regulator (Winged helix family Aggac_1613 ENOG4107S2Z UPF0761 membrane protein Aggac_1618 ENOG4105EQ2 LysR family Transcriptional regulator Aggac_1637 ENOG4107U2T alpha beta Aggac_1639 ENOG410804X Transcriptional regulator Aggac_1648 ENOG4105MA0 exported protein Aggac_1650 ENOG4105WH1 Two component transcriptional regulator luxr family Aggac_1654 ENOG4105ECF c-methyltransferase Aggac_1665 ENOG4105BZM domain protein Aggac_1669 ENOG4105C2J ABC transporter Aggac_167 ENOG4105CQC Prephenate dehydratase Aggac_1676 ENOG4105BZU Histidine kinase Aggac_1681 ENOG4105GXZ Ferredoxin-type protein NapH Aggac_1684 ENOG4106032 Glutathionylspermidine synthase Aggac_1685 ENOG4105XA0 heptosyltransferase ii Aggac_1690 ENOG4105CGH 5'-nucleotidase Aggac_1694 ENOG4105C2M dna polymerase I Aggac_1699 ENOG4107VXZ Hydrolase Aggac_170 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) Aggac_1700 ENOG4108UW5 maltose o-acetyltransferase Aggac_1719 ENOG4105D9N nucleoside Aggac_172 ENOG4105CPF Cell wall formation (By similarity) Aggac_1727 ENOG4105C31 Tryptophanyl-tRNA synthetase Aggac_173 ENOG4105DFU Cell wall formation (By similarity) Aggac_175 ENOG4105CNI cell division protein FtsW Aggac_1757 ENOG4105CS6 Rhs element vgr protein Aggac_176 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) Aggac_1775 ENOG4108HPI phosphatidate Cytidylyltransferase Aggac_178 ENOG4108EQQ Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein (By similarity) Aggac_1780 ENOG4105DAF Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) Aggac_1792 ENOG4105D0C transport protein Aggac_1794 ENOG41063SR receptor Aggac_1833 ENOG4105EW9 transcriptional regulator AsnC family Aggac_1848 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) Aggac_1857 ENOG4105BZ4 penicillin-binding protein Aggac_1858 ENOG4107SJW iron permease, FTR1 Aggac_1871 ENOG4105CQ7 ATP-dependent helicase Aggac_1882 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) Aggac_1887 ENOG4108ERU trap dicarboxylate transporter subunit DctP Aggac_1893 ENOG4105D7X high-affinity nickel-transporter Aggac_1907 ENOG4108Z7T Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) Aggac_191 ENOG4108JA2 transcriptioN-repair coupling factor Aggac_1911 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) Aggac_1920 ENOG4105C3F Signal peptidase i Aggac_1923 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) Aggac_1927 ENOG41076HS cation diffusion facilitator family transporter Aggac_1930 ENOG4107QPA Cleaves GlcNAc linked beta-1,4 to MurNAc tripeptides (By similarity) Aggac_1937 ENOG4107TZ2 Cell division protein that is required for growth during stress conditions. May be involved in protecting or stabilizing the divisomal assembly under conditions of stress (By similarity) Aggac_1942 ENOG4105E0U tyrosine-specific transport protein Aggac_1946 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein Aggac_195 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) Aggac_1950 ENOG4105II7 pyrroline-5-carboxylate reductase Aggac_1952 ENOG4105D8G Major Facilitator superfamily Aggac_1956 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) Aggac_1969 ENOG4105DFU Cell wall formation (By similarity) Aggac_1980 ENOG4105C28 cystathionine Aggac_1992 ENOG4105C3U ABC transporter Aggac_1994 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component Aggac_1995 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component Aggac_2005 ENOG4105EAH synthase Aggac_2014 ENOG4108UYE Lactoylglutathione lyase Aggac_2016 ENOG4105CXY transporter Aggac_2053 ENOG4105CTS PTS system mannitol-specific Aggac_2060 ENOG4105D7K pfkb domain protein Aggac_2066 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) Aggac_2071 ENOG4105C0A alcohol dehydrogenase Aggac_2075 ENOG4107QN8 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) Aggac_2094 ENOG4105CIH Imidazole acetol-phosphate transaminase Aggac_2095 ENOG4107QM1 Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) Aggac_2104 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate Aggac_2109 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) Aggac_2110 ENOG4105EW9 transcriptional regulator AsnC family Aggac_2112 ENOG4107Y7W Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) (By similarity) Aggac_2114 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter Aggac_213 ENOG4105C8J )-transporter Aggac_2142 ENOG4107WQX hydrogenase 4 membrane subunit Aggac_2163 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family Aggac_2164 ENOG4105C6Z Gluconate Aggac_2165 ENOG4105C4R Atp-dependent dna helicase Aggac_226 ENOG4105FNP Molybdopterin-guanine dinucleotide biosynthesis protein b Aggac_227 ENOG4108IXY short-chain dehydrogenase reductase Aggac_230 ENOG4105E7H involved in the assembly of LPS in the outer leaflet of the outer membrane. Determines N-hexane tolerance and is involved in outer membrane permeability. Essential for envelope biogenesis (By similarity) Aggac_236 ENOG4105C9U ATP-dependent DNA helicase RecQ Aggac_252 ENOG4108ESZ Glycogen debranching enzyme Aggac_255 ENOG4107QQN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) Aggac_259 ENOG41061WM D-Alanyl-D-Alanine Aggac_262 ENOG4105CEY Amp-dependent synthetase and ligase Aggac_274 ENOG4107SRH Nad-dependent epimerase dehydratase Aggac_279 ENOG4105CE6 Adenylation and deadenylation of glutamate--ammonia ligase (By similarity) Aggac_282 ENOG4105FB9 CRISPR-associated protein Aggac_286 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) Aggac_289 ENOG4105DWF phosphomethylpyrimidine kinase Aggac_291 ENOG4106SMU thiamine transporter membrane protein Aggac_295 ENOG4108W2Q Cytochrome d ubiquinol oxidase subunit III Aggac_310 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) Aggac_311 ENOG4107XGF functions in a salvage pathway. Uses pyridoxamine (By similarity) Aggac_337 ENOG4105K7D Required for maturation of 30S ribosomal subunits (By similarity) Aggac_341 ENOG4105C0D helicase Aggac_359 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) Aggac_364 ENOG4108EQH DNA internalization-related competence protein ComEC Rec2 Aggac_385 ENOG4105EHE chorismate mutase- prephenate dehydrogenase Aggac_406 ENOG4108TGR phosphatase Aggac_414 ENOG4105DT3 PTS system, galactitol-specific IIc component Aggac_433 ENOG4105CEP NADH dehydrogenase Aggac_445 ENOG4108VW9 Membrane Aggac_449 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) Aggac_457 ENOG4105C5H ABC transporter Aggac_458 ENOG4105C5H ABC transporter Aggac_465 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) Aggac_467 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate Aggac_473 ENOG4105E5Q amino acid AbC transporter Aggac_483 ENOG4105EJ2 Transcriptional regulator Aggac_507 ENOG4107RUE extracellular solute-binding protein family 1 Aggac_514 ENOG4105F3R pts system mannose fructose sorbose family iid Aggac_525 ENOG4105C93 Xylose Isomerase Aggac_529 ENOG4105W1Y Transcriptional regulator Aggac_535 ENOG4105DJF DNA polymerase III, delta' subunit Aggac_538 ENOG4105WV0 Glucose-6-phosphate 1-dehydrogenase (EC 1.1.1.49) Aggac_551 ENOG4107QPD alcohol dehydrogenase Aggac_583 ENOG4105WKS Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) Aggac_593 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase Aggac_61 ENOG4108TMH cytolethal distending toxin Aggac_623 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) Aggac_627 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit Aggac_633 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase Aggac_636 ENOG4105JIM Phosphatidylserine synthase Aggac_637 ENOG4105EIB trna rrna methyltransferase Aggac_639 ENOG41083KI ribonuclease, T2 Aggac_647 ENOG4105C7B Threonine dehydratase Aggac_649 ENOG4105CAK Cell division ATP-binding protein ftsE Aggac_65 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) Aggac_656 ENOG4105CV2 Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates (By similarity) Aggac_66 ENOG4105E9S glutaredoxin 2 Aggac_680 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) Aggac_694 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase Aggac_695 ENOG4105E0M Sulfatase Aggac_705 ENOG4105C25 Primosomal protein n' Aggac_708 ENOG4105W1T Glycosyl Transferase Aggac_734 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) Aggac_760 ENOG4105PE1 Receptor Aggac_761 ENOG4105PE1 Receptor Aggac_767 ENOG4105DFS Conserved Protein Aggac_771 ENOG4108MN8 Membrane Aggac_784 ENOG4108IUS Transketolase Aggac_792 ENOG41067MG lrgb family Aggac_795 ENOG4105C9B Cysteine desulfurase Aggac_800 ENOG4105DYS nad(p)h dehydrogenase (quinone) Aggac_810 ENOG4105R8X Outer membrane lipoprotein Slp Aggac_828 ENOG4105C1B dTDP-glucose 4-6-dehydratase Aggac_84 ENOG4105CVS RNA methyltransferase TrmH family, group 1 Aggac_850 ENOG4105DB7 PHP domain protein Aggac_852 ENOG4105CD8 aminopeptidase N Aggac_859 ENOG4105EHG Permease protein Aggac_869 ENOG4106ZKY Aggac_876 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) Aggac_881 ENOG4108Z4R 3-deoxy-d-manno-octulosonate 8-phosphate phosphatase Aggac_883 ENOG4105DDQ anthranilate synthase Aggac_893 ENOG4107QSA Oxaloacetate decarboxylase Aggac_896 ENOG4108MVK Receptor Aggac_9 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) Aggac_904 ENOG4105M7P phage repressor Aggac_906 ENOG4108MVK Receptor Aggac_909 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) Aggac_922 ENOG4105C2J ABC transporter Aggac_926 ENOG4105DAG ROK family Aggac_927 ENOG4105C5S asparaginyl-tRNA synthetase Aggac_928 ENOG4105KB2 stringent starvation protein b Aggac_933 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) Aggac_937 ENOG4105EQ6 Hydrolyzes dipeptides containing N-terminal aspartate residues. May play a role in allowing the cell to use peptide aspartate to spare carbon otherwise required for the synthesis of the aspartate family of amino acids (By similarity) Aggac_939 ENOG4105CUW cytochrome C-TYPE protein Aggac_940 ENOG4107QY8 reductase Aggac_951 ENOG4107QKA exodeoxyribonuclease V beta Aggac_97 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) Aggac_973 ENOG4108RS6 transposase Aggac_986 ENOG4105FDK ABC transporter Aggac_987 ENOG4105FAV ABC, transporter Aggac_997 ENOG410682Y Regulates arginine biosynthesis genes (By similarity)